This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical structure. This will enable highly specific localization of target biomolecules alongside chemical analysis of those molecules at the same high spatial resolution as fluorescence microscopy. Over the six-month period of performance beginning April 2, 2021, the awardee will work to demonstrate the feasibility of this breakthrough multimodal microscopy approach under the NIH's Biomedical Research and Research Training program (CFDA 93.859), which supports basic research increasing understanding of biological processes. If successful, FE-PTIR could offer profound benefits to biomedical research, such as insights into protein misfolding associated with neurodegenerative diseases.
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