Project Grant R43CA297979

Award Date 5/20/25
Completion Date 4/30/26
Dollars Obligated $296K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding to Osel, Inc., a biotechnology company based in Mountain View, California, to develop a novel antimicrobial approach to treat chemoradiation-resistant cervical cancer. The key products and services to be delivered under this $295,881 award, which runs from May 2025 to April 2026, are:

  1. Synthesis and characterization of a selective bacteriocin inhibitor, GASK7B, that can selectively kill the pathogenic Lactobacillus iners strain associated with decreased survival in cervical cancer patients undergoing chemoradiation treatment, without affecting beneficial Lactobacillus species.

  2. In vitro evaluation of GASK7B's potency, selectivity, safety, and stability, as well as its ability to reverse the resistance of cervical cancer cells to chemoradiation induced by the cancer-associated L. iners strain.

The goal is to establish GASK7B as a drug candidate and pave the way for future IND-enabling studies, providing a potential new treatment strategy for women with cervical cancer and dysplasia.

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