Project Grant R41CA306611
- This $1,107,943 Project Grant from the National Cancer Institute (CFDA 93.394 Cancer Detection and Diagnosis Research) was awarded to Illuminant Surgical Inc. to continue development and validation of the Skylight mixed-reality navigation platform for image-guided cancer biopsies. The key objectives of this Phase II effort are to: (1) develop and test software algorithms for tracking and compensating respiratory motion, (2) create a cadaveric model with physiologic respiratory movement for...
- This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) in the amount of $399,112 will be used by Imvaria Inc. to adapt its fully automated, AI-powered "DigitalBX" diagnostic tool for analyzing chest CT scans to detect pulmonary nodules suspicious of lung cancer. The goal is to provide an end-to-end automated diagnostic solution implemented as a secure cloud-based application that is fully reimbursable, alleviating the cost...
- The National Cancer Institute awarded a $452,540 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the Sloan-Kettering Institute for Cancer Research. The grant funds a 2-year project to investigate the use of electronic nose technology to predict and assess patient response to induction therapy and identify recurrence after curative-intent treatment for non-small cell lung cancer. The project aims to develop more accurate methods to evaluate therapy response and detect...
- This Project Grant award of $306,798 from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to develop an artificial intelligence-based system to accurately identify malignant lymph nodes. The key objectives are to: Create a lymph node segmentation model to enable extraction of radiomic features critical for malignancy classification. Develop both cloud-based and standalone desktop deployment options for the classification model to...
- The Project Grant award of $657,168 from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to The Trustees of the University of Pennsylvania will fund a study to complete IND-enabling preclinical studies and conduct a first-in-human clinical trial for a novel near-infrared fluorescent dye, JAS239, to guide lung cancer resection surgeries. The fluorescent dye is designed to target choline kinase A, an enzyme overexpressed in up to 85% of non-small cell lung...
- The National Cancer Institute (NCI) awarded a $323,548 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on optimizing lung cancer staging and treatment decisions. The 20-month project aims to compare two lymph node biopsy procedures - endobronchial ultrasound guided transbronchial node aspiration (EBUS) and mediastinoscopy - to assess their ability to detect the extent of cancer...
- This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $399,998 to Darwin Biosciences, Inc. to develop a low-cost, handheld, and non-invasive lung cancer screening device for use in low-resource settings. The device will incorporate sample collection, nucleic acid biomarker detection via isothermal recombinase polymerase amplification, and a visual readout on lateral flow strips. This work builds on Darwin Biosciences' prior...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Bullseye Biodevices, Inc. aims to develop a novel biosensing device for rapidly mapping volumetric tumor margins during surgical interventions for cancer. The key product under development is an electromechanical probe and sensor system that can generate real-time, 3D maps of tumor location and boundaries by measuring biophysical properties like force, deformation, and...
- The National Cancer Institute (NCI) awarded a $164,639 Project Grant (CFDA 93.394 - Cancer Detection and Diagnosis Research) to Brown University to develop a novel pipeline for kidney segmentation and registration based on deep learning techniques. The goal is to improve treatment efficacy and reduce recurrence rates for image-guided thermal ablation (IGTA), a minimally invasive cancer treatment. Specifically, the research will focus on detecting and mitigating potentially undetected...
- The National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) awarded a $1,233,778 Project Grant to Matrisome Bio, Inc. to develop an extracellular matrix-targeted theranostic radiopharmaceutical for treating metastatic lung cancer. The funding will support research and development efforts to create molecularly targeted drugs using nanobodies that specifically bind to disease-associated extracellular matrix proteins in lung tumors and metastases. This novel approach aims to...
The National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded a $225,229 Project Grant to Navigation Sciences Inc. on September 19, 2025. The grant will fund the development of a novel navigation software system, EndonaviSCI, to address key challenges in lung cancer surgery. The EndonaviSCI system aims to: 1) Ensure accurate localization and placement of a wireless electromagnetic sensor (J-bar) next to the tumor without the need for intraoperative imaging or palpation, and 2) Measure the true distance between the tumor and the surgical resection margin in the deflated lung, despite tissue deformation. This is intended to improve the accuracy of sublobar (segmentectomy) lung tumor resection, which preserves lung function but has a higher local recurrence rate compared to lobectomy. The project is expected to be completed by February 28, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $225.2k | 9/17/25 |