Project Grant R37AI188431
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $805,375 to the Icahn School of Medicine at Mount Sinai to conduct research on the tropism and pathogenesis of pararubulaviruses. The key objectives are to: 1) define the cellular tropism of Menangle and Sosuga viruses in human cells, 2) characterize the receptor usage pathways of these viruses, and 3)...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $455,692 Project Grant to the University of California, Berkeley to conduct research on the mechanisms that underpin bat virus virulence. The goal is to experimentally test predictions from the research team's theoretical model by carrying out experimental evolution of Vesicular Stomatitis Virus (VSV) in bat cell cultures that...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $929,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) on July 23, 2025. The grant supports research to investigate the mechanism of action of different vaccine platforms, including mRNA-based and Newcastle Disease Virus (NDV)-based vaccines, in inducing long-lasting protective systemic and mucosal immune responses against...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a Project Grant of $147,486.00 to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York, NY. The grant, awarded on January 26, 2025, will support research to characterize the immune landscape and define the mechanisms of immune dysfunction in chronic hepacivirus infection, using the Norway rat hepacivirus (NRHV) as a model....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $150,452 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Oklahoma. The grant will support a project titled "Molecular Testing of Predicted Bat Hosts for Zoonotic Hemoplasmas" from September 2025 to August 2027. The project aims to use machine learning models to prioritize bat species for molecular testing to identify potential zoonotic reservoirs of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $146,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Ghana to assess mechanisms for the persistence of RNA viruses in bat populations. The 5-year project, running from September 2025 to August 2030, aims to study virus prevalence, shedding, and spillover risk in captive and wild colonies of the straw-colored fruit bat (Eidolon helvum) in Ghana. The...
- The University of Texas Southwestern Medical Center (UT Southwestern) received a $454,726 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this 5-year award, with a start date of July 9, 2025 and a completion date of June 30, 2030, is to investigate cell-intrinsic antiviral mechanisms in bats, focusing on interferon-stimulated genes (ISGs) and their evolutionary...
- This $451,836 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), to The Washington University in Missouri. The purpose of the grant is to conduct a structural and mechanistic study of the bat NLRP6 inflammasome and its role in detecting RNA viruses, such as Ebola, Nipah, Hendra, and SARS-CoV, which bats can host without developing significant disease symptoms. The research...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $835,137 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to create a Repository of Monoclonal Antibodies (ROMA) for use in small animal models like hamsters and guinea pigs to evaluate infectious and inflammatory disorders. The project aims to develop a panel of monoclonal antibodies targeting surface markers on...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $452,475 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Colorado State University (CSU) to study adaptive immune responses in bats. The project aims to determine the effector functions of helper and cytotoxic T cells in response to bat influenza A and coronavirus infections, and evaluate the impacts of vaccination and T cell depletion on infection control. CSU will use a captive...
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, awarded a $805,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai. The grant, awarded on November 20, 2024, supports a 5-year research project to elucidate the cellular tropism, receptor usage, and pathogenesis mechanisms of emerging bat-derived pararubulaviruses, which pose a potential global health threat. The project, led by Drs. Lee and Lim, leverages complementary expertise in paramyxovirus entry/reverse genetics and advanced animal/human organ explant models to address critical knowledge gaps and guide the development of targeted medical countermeasures for this understudied virus group.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/22/25 | ||
| Not listed | $805.4k | 11/20/24 |