Project Grant R35GM162275
- Federal Project Grant Award Summary The University of California, San Francisco received a $576,104 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective August 15, 2025, with completion scheduled for July 31, 2030. The award supports fundamental research to elucidate the molecular and atomic-level mechanisms of integral membrane proteins, with particular emphasis on understanding how...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $410,256 Project Grant on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop generative multiscale models of biomolecular conformational dynamics. Over the five-year project period through July 31, 2030, Stanford will deliver computational tools that integrate physics-based modeling with artificial intelligence to...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $616,000 Project Grant on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling (PL) enzymes for mapping spatial proteomes in living cells. The research deliverables include the optimization and engineering of two novel PL enzymes—FLEXID and LACCID—designed to overcome limitations of existing...
- Federal Project Grant Award Summary The Leland Stanford Junior University received a $494,796 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through December 31, 2030. This award funds fundamental research investigating myosin structure and function, with particular emphasis on how hereditary mutations in cardiac myosin contribute to familial hypertrophic...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a $427,079 Project Grant effective August 1, 2025, through July 31, 2027, under the Biomedical Research and Research Training program (CFDA 93.859). The project, titled "DNA Transistors for Cellular Programming," focuses on developing innovative molecular tools that enable precise control over cellular functions using DNA-binding domains derived from nuclease technologies,...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $385,000 Project Grant to The Leland Stanford Junior University effective September 1, 2025, through June 30, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research to identify and characterize novel lipid transport and processing mechanisms evolved by Plasmodium parasites that interface with human cell physiology. The research...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a Project Grant of $2.1M (CFDA 93.859, Biomedical Research and Research Training) effective September 11, 2025, through August 31, 2029, to support research on the genetic basis of complex traits. The research focuses on developing and refining experimental and computational methods to identify genes and genetic variants underlying complex polygenic traits across...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $303,364 Project Grant on May 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply advanced microfluidic technologies for accelerated enzyme function analysis. The project, titled "Dissecting Enzyme Function at Scale Using Synergistic Advances in Microfluidics and Genetic Code Expansion,"...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $590,806 Project Grant to Stanford University, effective September 12, 2025, through August 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). Principal Investigator Ron Dror will develop computational and machine learning methodologies to advance structure-based drug discovery. The research deliverables include: (1) machine learning methods to predict...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Stanford University a Project Grant of $488,783 under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. This five-year Maximizing Investigators' Research Award (MIRA) funds fundamental research to decode the cell surface chemistry and function of Staphylococcus aureus, a gram-positive bacterium that poses significant challenges...
Stanford University received a $423,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 6, 2026, with completion scheduled for February 28, 2031. This award funds fundamental research aimed at dissecting the molecular mechanisms that regulate membrane protein complex assembly at the human endoplasmic reticulum (ER) membrane. The project employs an integrated approach combining genetics, cell biology, and structural biology to identify and characterize assembly factors that control voltage-gated ion channel (VGIC) biogenesis, using VGICs as model systems to understand how thousands of membrane proteins correctly identify and bind their binding partners to form functional complexes of defined stoichiometry. The research products and deliverables include the physiological characterization of two poorly understood VGIC assembly factors, the identification of novel assembly factors through systematic investigation, and mechanistic insights into endoplasmic reticulum membrane protein complex (EMC) chaperone functions in calcium channel assembly. The work incorporates advanced methodologies including fluorescent reporter cell lines, function-separating mutations, in vitro translation systems, and structural biology analysis. These findings are expected to advance fundamental understanding of membrane protein quality control pathways and address critical gaps in knowledge regarding diseases caused by mutations impairing VGIC biogenesis, including cardiological, neuropsychiatric, and neurodevelopmental disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 3/6/26 |