Project Grant R35GM161348
- Federal Grant Award Summary The University of Rochester received a $427,227 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through December 31, 2030. This award supports fundamental research investigating the mechanisms of action of gene-regulatory riboswitches—naturally occurring RNA molecules that sense metabolites and ions to control gene expression in bacterial...
- Federal Project Grant Award Summary The University of Rochester received a $414,159 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through July 31, 2030. This award funds fundamental research investigating the differential stress response mechanisms of cellular organelles under nutritional versus endoplasmic reticulum (ER) stress conditions. The research employs...
- Federal Grant Award Summary Rochester Institute of Technology received a $186,354 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award funds research to elucidate the functional roles of protein glycosylation in prokaryotes through comprehensive glycoproteomic analysis and characterization. The research employs an interdisciplinary...
- Federal Project Grant Award Summary The University of Rochester received a $367,808 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025 through May 31, 2030. This award funds research investigating the regulation and evolution of extreme metabolic plasticity in eusocial animals, with particular focus on understanding how metabolic and stress response pathways interact...
- Federal Project Grant Award Summary The University of Rochester received a $399,198 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with completion targeted for June 30, 2030. This five-year research initiative investigates the dynamics of cell-matrix mechanical communication during tissue and organ morphogenesis. The project will deliver fundamental research findings on...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $297,004 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate a modular chimeric tRNA synthetase (MOCHI-RS) system. This research aims to advance the incorporation of non-canonical amino acids into macrocyclic peptide therapeutics by engineering a "plug-and-play" platform that...
- Federal Grant Award Summary The University of Rochester received a $223,364 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) on September 12, 2025, to support the CTSA (Clinical and Translational Science Institute) Predoctoral T32 Training Program through August 31, 2030. The program delivers comprehensive workforce development services designed to cultivate the next generation of translational science researchers through mentored research...
- Federal Project Grant Award Summary Rochester Institute of Technology (RIT) received a $186,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, with a completion date of June 30, 2029. The award funds research into optimizing nanobody sequence design through multi-objective engineering—a computational and experimental approach to simultaneously predict and...
- Federal Grant Award Summary Emory University received a $196,460 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025 through February 29, 2028. The award supports fundamental research investigating the role of ribosomal RNA (rRNA) modifications, specifically 2'-O-methylation (NM), in regulating translation initiation—a critical cellular process for protein synthesis. The...
- Summary of Federal Grant Award The University of Texas Health Science Center at Houston has been awarded $868,584 under the Biomedical Research and Research Training program (CFDA 93.859), administered by the National Institute of General Medical Sciences within the National Institutes of Health. The project grant, effective from September 1, 2025, through August 31, 2027, supports fundamental research investigating how ribonucleic acid (RNA) modifications regulate adaptive messenger RNA...
The University of Rochester received a $578,733 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. The award supports fundamental research to elucidate the biological roles of transfer RNA (tRNA) modification enzymes and resolve critical knowledge gaps regarding how tRNA modifications impact cellular structure and function. The project will deliver integrated research combining biochemistry, molecular biology, and genetics methodologies, including development of new disease models and tools for detecting RNA modifications to decipher how modifications affect the global tRNA transcriptome. The research outcomes will reveal conserved and novel roles for tRNA modification enzymes, uncover tissue- and cell-specific functions linked to human disease, and identify new modes of gene regulation that could inform understanding and treatment strategies for human pathologies associated with tRNA modification. This foundational research addresses the molecular basis of pathogenic variants in tRNA modification enzymes that currently cause numerous diseases and disorders in the human population, with findings applicable to advancing disease diagnosis, treatment, and prevention capabilities.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $578.7k | 2/23/26 |