Project Grant R35GM160529
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,338,750 Project Grant to Yale University to conduct research on how gut bacteria can influence host feeding behavior and microbiome assembly using the roundworm Caenorhabditis elegans as a model system. The project aims to develop tools and assays to study the molecular mechanisms by which gut microbes can manipulate host feeding decisions, with the goal of gaining insights that may apply to other host-microbe systems. Key...
- This $388,750 federal Project Grant was awarded on September 19, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in University City, Missouri. The funding will support a 5-year research project to investigate the mechanisms driving host-associated microbial community dynamics, with a focus on understanding how environmental and host factors interact to shape gut microbiome...
- The National Institute of General Medical Sciences (NIGMS) awarded a $557,900 Project Grant to the Massachusetts Institute of Technology (MIT) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds a long-term research strategy to study ongoing adaptation and selective forces within human microbiomes. Using a culture-dependent genomic approach, the project aims to characterize within-person evolution over a dozen microbial species found in the skin, vagina,...
- This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to define molecular mechanisms underlying the gut microbiome's ability to resist colonization by pathogens like Vibrio cholerae. The $2,065,745 grant, awarded to the Regents of the University of California at Riverside, aims to provide a mechanistic understanding of how the biochemical environment of...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $1,759,395 Project Grant to the University of Oregon to investigate the hypothesis that "social microbiomes are major drivers of host health and sociality." The proposed research will use a zebrafish model to study how social interactions shape the microbiome, and how these "social microbiomes" impact host development, behavior,...
- This Project Grant award of $403,750 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to unravel the relationships between gut microbial signatures, blood microbial signatures, and immune responses in sepsis patients. The research will integrate gut microbial community profiling, metabolomics, intestinal permeability measures, and blood microbial signatures with immune phenotypes and clinical...
- This federal Project Grant award of $372,500.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Wisconsin-Parkside to characterize the enzymatic activities and metabolic functions of key gut bacteria in the Bacteroides genus. The research aims to provide clarity on fatty acid metabolism and coenzyme A availability within these bacteria, which have important implications for...
- This federal Project Grant award for $353,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the impact of xenobiotic exposure on the gut microbiome and its resilience against gastrointestinal pathogens. The research program aims to fill a critical knowledge gap by examining how xenobiotics and their biotransformation products affect the composition, metabolism,...
The National Institute of General Medical Sciences (NIGMS) awarded a $313,500 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Louisiana State University to investigate the role of gut microbiota in regulating endocrine signaling pathways involved in metabolic disorders such as Type 2 diabetes. The 5-year research project will utilize the C. elegans model organism and the university's Natural Microbiome Collection to map the genetic circuits connecting commensal bacteria to host endocrine function, including identifying enteroendocrine and neuronal signals and bacterial metabolites that trigger host responses. The goal is to enhance understanding of how gut microbiota modulate endocrine processes that influence energy balance and glucose metabolism, which could inform new strategies for treating metabolic diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $313.5k | 8/1/25 |