Project Grant R35GM160475
- This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $225,281 to Tulane University to develop sex-based human cell culture methods and microphysiological systems for studying sex differences in normal physiology and disease. The 5-year project will deliver validated culture medium formulations, engineered tissue models, and curricula integrating sex-based biology and medicine principles. This research aims to facilitate the...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $375,633 project grant to the University of Nevada, Las Vegas (UNLV) to develop an enhanced lipid nanoparticle (LNP) platform for selective and improved delivery of therapeutics in vivo. The key objectives are to: 1) investigate how LNP interactions with endogenous systems can be leveraged to redesign and improve delivery systems; and 2) examine how...
- This $375,134 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop a novel approach for reducing the off-target accumulation of chemotherapeutic nanomedicines. The key objectives are to characterize an innate immune response that can be leveraged to limit nanoparticle deposition in healthy tissues, thereby enhancing delivery to tumors and improving the efficacy of chemotherapy. The 5-year project, starting on March 1, 2025,...
- The U.S. Department of Health and Human Services' National Institutes of Health (NIH) awarded a $170,800 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to New York Blood Center, Inc. The goal of the research project is to understand the mechanism underlying sex-specific effects in the regulation of radiation response and to develop a novel radiation countermeasure that targets such differences. The project aims to determine the cellular and molecular mechanisms of LXN...
- This $650,000 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to Rowan University aims to develop and use lipid nanoparticles (LNPs) as tools to study the role of oxygen levels and immune activity during healthy and pathologic pregnancy. The goal is to uncover potential therapeutic strategies to treat diseases of pregnancy and other diseases characterized by low oxygen or excessive inflammation. This 5-year research project will...
- This $137,322 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research by Trustees of Boston University to develop disulfated polyamidosaccharide nanoparticles as a P-selectin targeting chemotherapeutic delivery system. The goal is to create a more targeted and effective treatment for breast and lung cancers, which disproportionately affect women, including many non-smokers. The research will leverage the upregulation of P-selectin on...
- The University of California, San Diego (UCSD) has been awarded a $1,422,000 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program. The research project, titled "Probing Sex Differences in Myocardial Fibrosis at Multiple Length Scales Using Biomaterials," aims to investigate how biological sex modulates myocardial fibrosis and develop innovative models of sex-specific tissue remodeling using advanced biomaterial...
- The federal Project Grant award for $191,300 was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The award supports a 4-year research program led by Dr. Thomas C. Binns, MD at Yale University to study the interactions between polymeric nanoparticles and phagocyte cell subpopulations in both healthy and disease states, with the...
- This $150,000 Project Grant was awarded on September 1, 2025 by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant will fund the "Waning Moon" intervention, a culturally tailored health education program designed to address menopause symptoms and cardiovascular disease risk in urban American Indian/Alaska Native women. The program will provide education on conventional and complementary...
- This National Science Foundation (NSF) Engineering Program project grant awarded to the Massachusetts Institute of Technology (MIT) provides $429,384 in funding to study how drug nanoparticles adhered to leukocyte (white blood cell) surfaces influence their mechanical properties and movement through microscale blood vessel networks. The 5-year research effort, from March 2024 to February 2029, will use a combination of biophysical models and microfluidic experiments to generate fundamental...
This $1,833,094 Project Grant awarded by the Department of Health and Human Services' National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) aims to advance the field of nanomedicine by uncovering the mechanisms underlying sex differences and female life stage variations in drug delivery. The key objectives are to systematically evaluate nanoparticle performance across cellular, microenvironmental, and systemic levels to identify the factors impacting delivery and efficacy in males versus females, as well as how menstrual cycle, hysterectomy, and menopause affect nanoparticle transport and biodistribution. The 4-year project, awarded to the University of New Mexico, will utilize a library of clinically relevant lipid- and polymer-based nanoparticles to address these critical gaps in understanding sex and female life stage differences in nanomedicine, with the goal of enabling more tailored, effective, and equitable nanomedicine designs.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 8/13/25 |