Project Grant R35GM160316
- This federal Project Grant award of $222,708 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanistic basis of individual and clustered enhancers in human cells. The goal is to elucidate the molecular mechanisms underlying long-range enhancer-promoter interactions and the role of enhancer clusters in regulating gene expression, with a focus on the MYC locus. The...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $129,708 Project Grant to the Fred Hutchinson Cancer Center in Seattle, Washington. The grant supports the development of robust computational tools to model and interpret complex single-cell data, with the goal of uncovering mechanisms of cell differentiation and cancer progression. Key objectives include creating applications based on a novel...
- The National Institute of General Medical Sciences (NIGMS) awarded a $298,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Epigenter, LLC in Providence, RI. The grant supports the development of "Epigenetic Editor Therapeutics" - a novel approach to modulating gene expression without altering the DNA sequence. The project aims to create recombinant, self-delivering epigenetic editor proteins that can be taken up by cells and targeted to...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- This federal Project Grant award of $484,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Fred Hutchinson Cancer Center in Seattle, Washington. The award will support a research project titled "Defining Mechanisms that Underlie Well-Controlled Translation Initiation" over the period from September 1, 2025 to August 31, 2030. The project aims to use innovative...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The National Institute of General Medical Sciences (NIGMS) awarded Epicypher, Inc. a $1,264,176 project grant under the Biomedical Research and Research Training federal grant program (CFDA 93.859) to develop a novel toolbox for studying how asymmetric post-translational modifications (PTMs) on nucleosomes regulate chromatin biology. The key products and services to be delivered include: A novel manufacturing method to efficiently generate asymmetric designer nucleosomes (A-dNucs) at...
- The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 - Biomedical Research and Research Training is supporting a $3,125,817 research project at New York University School of Medicine titled "Decoding Positional Epigenetic Memory." The project aims to decipher how stable positional identity is generated through the regulation of HOX gene expression, which is crucial for proper cell differentiation and disease...
This Project Grant award, titled "Mapping and Prediction of Epistatic Enhancer Interactions in Gene Regulation," is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $484,000 award to the Fred Hutchinson Cancer Center in Seattle, WA supports research to elucidate the principles of how enhancers coordinate to control gene transcription and the transcription factors they utilize. The project aims to map enhancer epistatic interactions using multiplexed CRISPR perturbation approaches and leverage new technologies like single-cell RNA sequencing and deep learning to model the interactive effects of noncoding variants on gene expression and disease pathogenicity. The award period runs from September 15, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $484.0k | 9/8/25 |