Project Grant R35GM160188
- This $361,283 Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Yale University focused on advancing the fields of molecular structure analysis and molecular dynamics simulations. The research aims to develop novel methods and algorithms that leverage cutting-edge techniques like cryo-electron microscopy and molecular...
- The Federal Grant Award of $669,737.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The award, with a performance period from September 1, 2025 to August 31, 2027, supports a research project focused on investigating the principles underlying convective cell motion and its coordination with cell migration within tissues. The research aims to provide fundamental insights...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This $240,000 federal Project Grant award from the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070) is supporting research at Yale University to develop new computational frameworks that combine large language models with neural operator learning techniques. The goal is to improve the ability to model and analyze spatiotemporal phenomena in biomedical research, such as tracking cellular and brain processes over time and...
- This federal Project Grant award of $256,616.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to develop a graph theory toolbox for uncovering redundant pathways in genetic interaction networks. The research will focus on analyzing the fine-scale graph-theoretic structure of genetic interaction networks to identify mechanisms of redundancy and fault tolerance in biological...
- This federal Project Grant award of $669,801 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Yale University to study the proteomic and phosphoproteomic remodeling associated with genomic imbalances, such as in aneuploid cells. The research aims to distinguish the mechanisms of proteomic remodeling and tolerance in chromosome gain versus loss type aneuploidies, as well as to apply...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is providing $460,625.00 to the University of Massachusetts Medical School (UMASS Medical) to reconstruct gene regulatory networks (GRNs) using population-scale and atlas-scale single-cell datasets. The goal is to overcome challenges in data sparsity and scalability, as well as limitations in existing causal inference methods...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe population-wide phenomena in these complex living systems. The award has a start date of September 15, 2025 and an ultimate completion date of July 31, 2030. This research aims to advance the understanding of how fundamental biological functions and structures emerge from intricate webs of interactions at smaller scales.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.7k | 9/8/25 |