Project Grant R35GM160123
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is providing $460,625.00 to the University of Massachusetts Medical School (UMASS Medical) to reconstruct gene regulatory networks (GRNs) using population-scale and atlas-scale single-cell datasets. The goal is to overcome challenges in data sparsity and scalability, as well as limitations in existing causal inference methods...
- The National Institute of General Medical Sciences (NIGMS) has awarded a $536,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Sanford Burnham Prebys Medical Discovery Institute (SBP). The project aims to develop computational methods that can analyze single-cell transcriptomic data to better identify and study rare cell populations, such as tissue stem cells, senescent cells, and tumor-initiating cells. The approach will use...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $410,014 Project Grant to Trustees of Boston University to establish proof-of-concept for a new high-speed, real-time feedback-driven single particle tracking (RT-FD-SPT) fluorescence microscope with concurrent spectroscopic readout. The goal of this project is to develop an advanced tracking approach that leverages dual-stage scanners and nonlinear...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,616 Project Grant to Brown University. The grant, effective from September 1, 2025 to June 30, 2030, will support the development of integrative computational models to decode disease mechanisms and predict drug synergies in spatial transcriptomics. The research aims to uncover how the spatial arrangement of cells within tissues (cellular spatial...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded a $384,722 Project Grant to Emory University to develop statistical approaches for integrating multi-view, multi-section, and multi-sample spatial transcriptomics data to decipher disease mechanisms. The project aims to provide researchers with analytical tools to tackle challenges in population-scale spatial transcriptomics data analysis, beginning...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $380,587 to The Johns Hopkins University from January 1, 2025 to December 31, 2029. The project aims to develop new integrated technologies to investigate how distinct molecular programs drive cell behaviors and cellular responses to perturbations at single-cell resolution. The research will focus on understanding...
- This $694,875 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Boston University Medical Campus to advance the understanding of G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling plasticity. The research aims to define the physiological implications of non-GPCR activation of G proteins and develop innovative tools to measure G protein activity....
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports advanced quantitative analyses of long-read RNA sequencing data at both the bulk and single-cell levels. The $424,264 award, effective June 1, 2025 through May 31, 2030, will enable the University of Michigan to build upon their expertise in long-read sequencing bioinformatics and deliver new insights into...
The U.S. Department of Health and Human Services, National Institute of General Medical Sciences (NIGMS) awarded a $449,625 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Trustees of Boston University. The grant, awarded on September 15, 2025, supports research to develop new experimental strategies and computational approaches for studying single-cell gene expression trajectories. The overarching goal is to enable foundational advances in understanding the dynamic regulation of RNA production, processing, and degradation, which underlie a wide range of biological processes and disease progression. The research will leverage an interdisciplinary approach integrating experimental systems biology, genomics, machine learning, and data science to chart the phenotypic space that individual cells can occupy through their expression trajectories.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $449.6k | 9/9/25 |