Project Grant R35GM158209
- This federal Project Grant award of $423,750.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on May 1, 2025, supports a research project at New York University (NYU) School of Medicine to develop new conceptual and statistical approaches that integrate molecular, cellular, and population genetics to better understand the genetic basis of complex human traits and diseases....
- This federal Project Grant award of $508,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at St. Jude Children's Research Hospital Inc. to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis. The research focuses on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to dynamically change H3K27...
- This federal Project Grant award of $427,571.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project titled "Maintenance of Cellular Memory During Replication" at the University of Colorado-Denver. The project aims to uncover the molecular determinants of cellular identity and how chromatin states are regulated across the cell cycle. Key objectives...
- This federal Project Grant award of $2,203,340.00, awarded on September 20, 2025 by the National Institute of General Medical Sciences (NIGMS), is part of the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research to define the mechanistic rules governing how transcription factors (TFs) bind to chromosomal DNA within compacted chromatin. The goal is to systematically dissect the factors required for initial and sustained TF binding to...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA program 93.859 - Biomedical Research and Research Training, provides $333,076.00 to New York University (NYU) to develop novel statistical methods, algorithms, and pipelines for learning from complex, heterogeneous omics data. The project aims to innovate in studying subgroups within genomic, transcriptomic, or connectomics data, even amidst potential data shifts and multidimensional...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award of $222,708 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanistic basis of individual and clustered enhancers in human cells. The goal is to elucidate the molecular mechanisms underlying long-range enhancer-promoter interactions and the role of enhancer clusters in regulating gene expression, with a focus on the MYC locus. The...
- The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $2,129,028 Project Grant to New York University (NYU) under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural dynamics and function of long non-coding RNAs (lncRNAs). The research project aims to establish NYU as a world-leading expert in connecting lncRNA structural dynamics to their biological functions. The research team, which includes high school, undergraduate,...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 - Biomedical Research and Research Training is supporting a $3,125,817 research project at New York University School of Medicine titled "Decoding Positional Epigenetic Memory." The project aims to decipher how stable positional identity is generated through the regulation of HOX gene expression, which is crucial for proper cell differentiation and disease prevention. Key research objectives include understanding how patterning signals regulate Polycomb repressive complexes and CTCF-established chromatin boundaries to establish precise and stable HOX gene expression domains. The award has a performance period from August 5, 2025 to July 31, 2029 and is part of NIGMS's broader efforts to advance fundamental scientific research with potential long-term implications for human health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 8/5/25 |