The National Institute of General Medical Sciences (NIGMS) awarded a $408,750 Project Grant to Trustees of Boston University to develop synthetic oligonucleotide nanostructures that can program interfacial interactions at immune interfaces. The goal is to uncover the impact of molecular cargo packaging on immunomodulation. This 5-year project will explore two focus areas: 1) how cargo component spacing modulates receptor interactions and affects signal propagation, and 2) the role of anisotropy at the nano-immune interface. The research aims to generate insights for elevating immunotherapeutic potency across various drugs and diseases. This award falls under the NIGMS Biomedical Research and Research Training program (CFDA 93.859), which supports a wide range of scientific research and educational activities in the biomedical sciences.