Project Grant R35GM157321
- This $462,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to establish the epigenetic mechanisms that govern embryonic stem cell (ESC) biology. The research aims to define how ESC gene expression programs and biology are regulated by DNA methylation and the TET family of DNA demethylases. Key objectives include: Dissecting the molecular and biological requirements...
- This Project Grant award of $394,434 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research program entitled "Decoding Epigenetic Adapters of Cell State" at the University of Alabama at Birmingham (UAB). The project aims to mechanistically interrogate the epigenetic contribution to cellular identity by examining the regulation of RNA polymerase II checkpoints, defining how gene body...
- This federal Project Grant award of $508,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at St. Jude Children's Research Hospital Inc. to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis. The research focuses on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to dynamically change H3K27...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This federal Project Grant award, valued at $365,625.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the mechanisms by which TET family enzymes act on 5-methylcytosine in genomic DNA and to exploit these insights to devise controllable epigenome editors. The research, conducted by The Trustees of the University of Pennsylvania, will focus on understanding cytosine...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- The National Institute of General Medical Sciences (NIGMS) awarded a $508,315 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, San Diego (UCSD) to investigate the molecular mechanisms required for successful developmental progression from oocyte to embryo during a critical window of transcriptional silence in mammals. The overarching goal is to uncover post-transcriptional regulatory mechanisms, such as mRNA poly(A) tail dynamics, that...
- This $445,000 federal project grant was awarded on January 23, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research conducted by the Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California, to elucidate the molecular mechanisms by which protein arginine methylation regulates gene expression, RNA metabolism, and human biology and...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This federal Project Grant award of $222,708 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanistic basis of individual and clustered enhancers in human cells. The goal is to elucidate the molecular mechanisms underlying long-range enhancer-promoter interactions and the role of enhancer clusters in regulating gene expression, with a focus on the MYC locus. The...
This federal Project Grant award for $380,540.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, supports research to investigate the relationship between DNA methylation and microRNAs during early human embryonic stem cell lineage specification. The research program seeks to dissect the early cell fate changes due to epigenetic regulation using omics technologies, cell imaging, and transcriptional regulator expression changes. It will explore the interplay between DNA methylation and microRNAs to regulate gene expression during normal and abnormal differentiation. The project also aims to determine the most suitable methods for directed differentiation and cell state identity, such as pan-mesoderm differentiation and methods that differentiate cells through a specific mesoderm subtype. The award has a performance period from September 1, 2025 to June 30, 2030 and is being provided to the University of California, Irvine, a prominent public research university.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $380.5k | 8/22/25 |