Project Grant R35GM157055
- This $326,550 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training (CFDA 93.859) program supports research to develop computational tools and statistical methods to model and design complex microbiome communities. The project aims to: Build tools to identify functionally significant taxa groupings in diverse microbiome ecosystems like marine, soil, and gut environments. Create methods to design synthetic microbial...
- The National Institute of General Medical Sciences (NIGMS) awarded a $421,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the President and Fellows of Harvard College to conduct research on "Deciphering and Predicting Ecologically Sensitive Gut Microbiome Contributions to Human Metabolic Health". Over the 5-year project period from September 2025 to June 2030, the research aims to elucidate how lifestyle factors like diet, exercise, and...
- This $313,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the interplay between gut microbiota and endocrine signaling in the model organism C. elegans. The project aims to map the genetic circuits connecting commensal bacteria to host endocrine regulation, identify enteroendocrine and neuronal signals involved, and characterize the bacterial metabolites that...
- The National Institute of General Medical Sciences (NIGMS) awarded a $353,500 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of California at Riverside. The award will fund research to investigate how exposure to xenobiotic compounds (non-antibiotic drugs, pesticides, plasticizers, etc.) affects the gut microbiome and its resilience against gastrointestinal pathogens like Salmonella and Vibrio cholerae. The research aims...
- The National Institute of General Medical Sciences (NIGMS) awarded a $382,931 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to The Washington University in Missouri. The grant, which runs from Sep 1, 2025 to Aug 31, 2030, supports research to "Decode Mitochondrial AAA Protease Specificity". As a leading research institution, The Washington University leverages its expertise across multiple scientific disciplines to execute complex federal...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,338,750 Project Grant to Yale University to conduct research on how gut bacteria can influence host feeding behavior and microbiome assembly using the roundworm Caenorhabditis elegans as a model system. The project aims to develop tools and assays to study the molecular mechanisms by which gut microbes can manipulate host feeding decisions, with the goal of gaining insights that may apply to other host-microbe systems. Key...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $557,900.00 to the Massachusetts Institute of Technology (MIT) to study ongoing adaptation and selective forces within human microbiomes. The research aims to develop intuition, rules, and exceptions regarding within-person evolution and adaptation across diverse microbial species found in the skin, vagina, and large...
- This $427,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a novel nano-prodrug delivery platform to target microbiome-modulating molecules to the distal gastrointestinal (GI) tract. The project aims to reveal the bidirectional interactions between microbiome composition and prodrug metabolism, exploring how variations in the gut microbiome influence drug...
- This $2,065,745.00 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to define the molecular mechanisms underlying the gut microbiome's ability to resist colonization by pathogens like Vibrio cholerae, the cause of cholera. The research will examine how small molecule signaling factors, including bacterial quorum sensing autoinducers and microbial metabolites, modulate the gut...
- This Project Grant award of $422,931 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Colorado-Denver to characterize the role of natural product-mediated microbial interactions within the human microbiome. The project aims to integrate cheminformatics analysis of metabolomics data with in vitro model systems to elucidate novel chemistry that contributes to the recalcitrance of...
The National Institute of General Medical Sciences (NIGMS) awarded a $388,750 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to The Washington University in University City, Missouri. The 5-year grant, awarded on September 19, 2025, supports research to investigate the drivers of gut microbial community dynamics, with a focus on examining how environmental and host factors interact to shape microbial communities over an individual's lifespan, understanding how normal variation in host physiology influences the gut microbiome, and revealing the mechanisms by which host physiology contributes to gut microbiome variation. The research leverages metagenomics, behavioral observations, and non-invasive methods to track associations between environmental changes, host physiology, and the gut microbiome in both wild animal systems and humans.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.8k | 9/18/25 |