This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $884,888 to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on the molecular mechanisms underlying sex differences in wound healing.
The key objectives of this 18-month study are to: 1) develop improved in vitro systems to study how sex hormones like testosterone and estradiol modulate wound healing cell behaviors; 2) define how testosterone impacts the immune response and resultant wound repair outcomes; and 3) profile the effects of estradiol on wound healing immune cell subtypes and the cytokine milieu, including how sex chromosome complement modifies these responses. The ultimate goal is to advance scientific understanding of hormone-mediated sex differences in wound healing biology, with the potential to improve care for marginalized patient populations and develop new therapeutic approaches for chronic wounds.
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