Project Grant R35GM156342
- This $406,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports two primary research directions at the University of Pennsylvania. The first research direction focuses on understanding how transcription factor families coordinate complex developmental pathways to generate diverse cellular morphologies and cell types, with a focus on identifying new mechanisms of transcription...
- The University of Pennsylvania received a $406,250.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The grant, awarded on January 22, 2025, supports a research project titled "Implementing the Nascent ECM into the Dynamic Reciprocity of Cell-ECM Interactions." This project aims to develop and apply engineering tools to better understand cell-cell and...
- This federal Project Grant award, valued at $365,625.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the mechanisms by which TET family enzymes act on 5-methylcytosine in genomic DNA and to exploit these insights to devise controllable epigenome editors. The research, conducted by The Trustees of the University of Pennsylvania, will focus on understanding cytosine...
- This $406,250 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to develop novel computational methods that can accurately characterize the reorganization of water structure and its impact on the thermodynamics and kinetics of protein interactions. This will be applied to three specific projects: (1) interactions between reader proteins and...
- This federal Project Grant award of $446,875.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress. The primary awardee, The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, will leverage their expertise in...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award for $440,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program at Northwestern University that investigates how RNA modifications, known as the epitranscriptome, regulate the translation of mRNA into proteins and how this interplay affects cell responses to stress. The research aims to fill gaps in understanding of how...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- This Project Grant award of $429,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the biogenesis and function of cyclic phosphate-containing small non-coding RNAs (CP-RNAs). The award, effective February 8, 2025 through December 31, 2029, will enable a genome-wide expression analysis of short CP-RNAs across various cells and tissues. Key objectives include: 1) determining that...
- The National Institute of General Medical Sciences (NIGMS) awarded a $854,927 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in Missouri. The grant, effective September 5, 2025 through August 31, 2027, will support research to define the mechanisms of a new pathway for genome stability, known as RNA Damage Induced DNA Breaks (RDIBS). The key objectives are to identify the types of RNA modifications that activate RDIBS, the...
The University of Pennsylvania was awarded a $443,806 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental scientific research investigating the collective impacts and regulatory mechanisms of multiple enzyme-mediated modifications across distinct RNA species, particularly in the areas of mRNA, tRNA, and rRNA. The research aims to uncover the extent of crosstalk in translation and whether the collective impacts of modifications in distinct RNA species exhibit nonlinearity beyond simple additive effects. The award period runs from September 1, 2025 to June 30, 2030 and the research will employ a range of methodologies including biochemistry, molecular biophysics, RNA biology, and structural biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $443.8k | 8/28/25 |