This $388,135 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to characterize bioelectrical signaling between gut microbiota and the mammalian host. The primary objectives are to study the production and functional implications of conductive nanowires in human gut microbes, and to explore the bidirectional interactions between gut microbes and their host. The research seeks to uncover the precise mechanisms of gut-host communication at the cellular and molecular levels, with potential implications for developing innovative bioelectrical therapeutic strategies for intestinal and systemic conditions. The grant was awarded to the Trustees of Indiana University, doing business as Indiana University Indianapolis, a major state-controlled research institution, on July 1, 2024. The project is expected to run through June 30, 2029.
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