The University of Kansas Center for Research Inc. was awarded a $376,738 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant aims to uncover the fundamental biochemical mechanisms governing riboregulatory interactions involving the hepatitis C virus 3'X RNA. The research will use single-molecule FRET spectroscopy, cryo-electron microscopy, and other techniques to determine the structural, energetic, and kinetic principles that govern these critical RNA-RNA interactions. The insights gained will enhance the understanding of hepatitis C virus biology and regulation, and potentially impact broader areas of RNA biology beyond this specific viral system. The grant award period runs from September 1, 2024 to July 31, 2029.
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