Project Grant R33CA302632
- This Project Grant award from the National Cancer Institute (NCI), under the Federal Assistance Listings program CFDA 93.395 Cancer Treatment Research, provides $406,500.00 to support the development of a novel, low-cost, single-use trans-nasal cryotherapy device for esophageal cancer treatment in low-resource settings. The project aims to design and validate a functional prototype of this first-of-its-kind device, which would enable unsedated cryoablation procedures to be administered through...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $273,388 to Histone Therapeutics, a woman-owned small business, aims to epigenetically modify natural killer (NK) cells to enhance their ability to detect and kill cancer cells. The goal is to develop a broad-spectrum NK cell therapy that can be used in combination with current cancer treatments to improve effectiveness without increasing side effects. The project will assess...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $3,182,665 to The Washington University to investigate how natural killer (NK) cells can subvert the effectiveness of immune checkpoint therapy for cancer treatment. The key objectives are to: 1) elucidate the mechanisms by which NK cells constrain the efficacy of immune checkpoint therapy, 2) evaluate the contribution of the NKG2D receptor in this process, and 3) translate the findings...
- The National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research Federal Grant Program (CFDA 93.394), awarded a $399,444 Project Grant to Cancure LLC (Canzx Biotherapeutics) on August 1, 2025. The funding will support a feasibility study of a novel agent that aims to stimulate NK (natural killer) and CD8 T cells for potential use in treating solid tumors. The study seeks to address challenges with persistence and sustained function of these cell-based therapies in the solid...
- The Regents of the University of Minnesota received a $299,992 Project Grant award from the National Science Foundation to support the development of next-generation cryopreservation media for natural killer cells under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The two-year project period runs from May 1, 2021 through April 30, 2023. The NSF Technology, Innovation, and Partnerships program seeks to advance science and engineering research and innovation leading to...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $2,253,869 to Celdara Medical, LLC to develop CM-HZ01, a novel non-alpha-IL2 therapeutic for the treatment of metastatic melanoma. The funding supports advancing CM-HZ01 to the Investigational New Drug (IND) application stage, with the goal of providing a best-in-class immunotherapy for patients with limited effective treatment options for this deadly form of skin cancer. The project...
- This federal Project Grant award of $1,340,987 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to revolutionize chimeric antigen receptor (CAR) T-cell therapy by developing a novel CAR-enhancer platform. The platform seeks to augment the functionality and longevity of CAR T-cells, addressing the key challenge of limited durability of response in patients. The specific objectives of this 24-month project are to: 1) Optimize dosing and timing for administering the...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $192,564.00 to The Ohio State University to develop a natural killer (NK) cell-based immunotherapy for the treatment of pediatric solid tumors. The key objectives are to explore a novel monomeric chimeric antigen receptor (CAR) design to optimize NK cell signaling and function, and to define a donor selection algorithm for CAR NK cell products. The award aims to leverage the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 in funding to Cisterna Biologics, Inc. to develop a novel mRNA production and purification process. The key objectives are to: Optimize psychrophilic (cold-adapted) RNA polymerases and synthetic promoters to minimize contaminants in mRNA synthesis, improving safety and efficacy for therapeutic use. Implement...
- This $399,669 federal Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to establish the feasibility of commercializing a personalized and multi-targeted adoptive T cell therapy (ATCT) for glioblastoma (GBM), the most common and deadly primary brain tumor. The key products or services to be delivered under this grant include: Evaluating the ability of the applicant's Prussian blue nanoparticle-based photothermal therapy (PBNP-PTT) platform to...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $292,963.00 to Cryocrate LLC, a for-profit company based in Missouri, to develop a novel biocompatible and high-throughput cryopreservation medium called Odinsol for enhancing the post-thaw viability and functionality of natural killer (NK) cells in cancer immunotherapy applications. The key objectives of this 3-year project are to: 1) optimize Odinsol to preserve NK cell migration, cytotoxicity, and cytokine production; 2) produce a GMP-compliant prototype batch with verified stability and quality control; and 3) validate the in vivo safety and efficacy of Odinsol in an animal model to secure FDA clearance for clinical use. The successful development of this advanced cryopreservation technology aims to improve the manufacturing and clinical application of NK cell therapies, making them more scalable, effective, and accessible for cancer treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $293.0k | 9/16/25 |