Project Grant R21NS142822
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Scripps Research Institute a $710,155 Project Grant effective February 1, 2026, through January 31, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year research initiative will advance fundamental understanding of post-transcriptional mechanisms governing cortical inhibitory interneuron (CIN) development and...
- This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $519,166 Project Grant to the Research Institute at Nationwide Children's Hospital on August 8, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research project focuses on the preclinical development of vectorized exon skipping (VES) therapy for Duchenne Muscular Dystrophy (DMD) exon 44 mutations, with an...
- Federal Grant Award Summary Baylor College of Medicine received a $124,106 Project Grant award dated April 1, 2026, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year research project, scheduled for completion by March 31, 2028, investigates the molecular mechanisms underlying neurological manifestations in Myotonic Dystrophy Type 1 (DM1), a progressive...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Wisconsin–Madison a Project Grant totaling $494,240 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective February 16, 2026, through January 31, 2031. This award funds a five-year research investigation into microRNA (miRNA) degradation mechanisms in post-stroke brain tissue, specifically examining...
- Federal Project Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $429,000 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, obligated on May 15, 2025, supports research through April 30, 2027, and is being conducted in Pennsylvania. The funded research project investigates somatic...
- Federal Project Grant Award Summary Albany Medical College received a $562,051 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded March 6, 2026, with a completion date of February 28, 2031. The award supports research investigating the modulation of the Hippo pathway as a novel therapeutic approach for Charcot-Marie-Tooth Disease Type 1A...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York a $644,965 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for the period of February 1, 2026, through January 31, 2031. This research initiative investigates phylogenetic differences in motor neuron development between humans and mice using human induced...
- Federal Grant Award Summary The University of Minnesota received a $226,139 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2025 through June 30, 2027. The primary deliverable is the development and characterization of a human cerebellar organoid model of Spinocerebellar Ataxia Type 1 (SCA1), a dominantly inherited...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $599,005 project grant to the University of Miami's Office of Research Administration on August 21, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will be conducted in Florida and is scheduled for completion by July 31, 2030. This award supports investigator-initiated basic and translational research...
This project grant, awarded March 2, 2026, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), provides $420,750 in funding to Iowa State University to conduct transcriptome and proteome analysis of circular RNAs (circRNAs) derived from Spinal Muscular Atrophy (SMA) genes. The research focuses on characterizing the molecular effects of three primary SMA-related circRNAs—C2A-2B-3-4, C2B-3-4, and C3-4—through systematic examination of gene and protein expression changes in multiple cell models, including human embryonic kidney (HEK293), cervical cancer (HeLa), neuronal (SH-SY5Y), motor neuron-like (NSC-34) cells, and patient-derived fibroblasts. The project deliverables include comprehensive transcriptome and proteome datasets generated through analysis of inducible cell lines stably overexpressing each circRNA variant, expanded studies examining transient circRNA expression across diverse cell types, and investigation of circRNA depletion effects. These analyses are designed to elucidate the functional roles of SMA-related circRNAs and their potential application as novel diagnostic and therapeutic biomarkers for spinal muscular atrophy, a leading genetic cause of infant mortality. The award period extends through February 29, 2028, with research activities conducted at Iowa State University's facilities in Ames, Iowa.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.8k | 3/2/26 |