Project Grant R21NS140910
- This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of complement-mediated inflammation in exacerbating stroke outcomes in mice with type 2 diabetes. The total award amount is $604,795.00 and the project period runs from December 1, 2024 to November 30, 2029. The awardee, Northern...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the...
- This $238,410 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) supports research at the University of California, San Francisco (UCSF) to identify protective and harmful mechanisms of acid-base physiology relevant to ischemic stroke. The project's objective is to determine how adjusting systemic and cerebral levels of carbon dioxide and hydrogen ions can improve metabolic supply, inhibit spreading depolarizations, and reduce stroke size in mouse...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), provides $626,034 to The Regents of the University of California, San Francisco (UCSF) to conduct research on identifying cortical and brainstem regions contributing to partial hand function post-stroke. The research aims to investigate the neural mechanisms underlying the preserved ability...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
- This federal Project Grant award of $629,031.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel label-free, live-cell classification system for neural stem cell activation state. The award aims to leverage fluorescence-lifetime imaging (FLIM) and analysis of cellular metabolites and autofluorescence to non-invasively track neural...
- This $520,025 Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop new peptide nucleic acid (PNA) inhibitors targeting the miR-141-3p microRNA for potential stroke therapy. The research focuses on synthesizing and characterizing more potent gamma-PNA (GPNA) analogs of the miR-141-3p inhibitor, with the primary goal of...
This Project Grant award of $438,625.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of California, San Diego (UCSD) to characterize and augment a novel pro-survival mechanism in neurons during ischemic brain injury. The research aims to investigate the role of the protein INF2 in driving "actinification", a reorganization of the neuronal actin cytoskeleton that confers temporary neuroprotection in ischemic conditions, using mouse models of stroke. The project seeks to determine if overexpression of INF2 can protect neurons from ischemic injury, with the goal of developing new therapeutic approaches for stroke. The award period runs from August 7, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $438.6k | 8/6/25 |