This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $203,390.00 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research measuring the interactions between adenosine 2A receptors (A2AR) and dopamine D2 receptors (D2R) in the striatum, both in non-human primates and in human subjects. The primary objectives are to use PET/MRI neuroimaging to quantify the level of receptor occupancy required to modulate the other receptor system, and to investigate the impacts of modulating D2R by an A2AR antagonist (caffeine) on reward learning behaviors in humans. This research aims to provide translational evidence supporting the functional existence of A2AR-D2R heterodimers, which could lay the foundation for future clinical investigations of adenosine-based hypotheses in psychiatric disorders. The award period runs from February 19, 2025 to January 31, 2027.
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