Project Grant R21MH133078
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will pilot an adaptation of the Mothers and Babies (MB) program to target perinatal depression in expectant mothers and new parents of infants with Down syndrome. The $720,000 award will be used to co-design and evaluate additional MB program content to address the specific needs of this population, including mechanisms of grief/loss and social support. The...
- This federal Project Grant award of $418,178 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to provide mechanistic insights into the neurobiological mechanisms by which maternal sensitivity is compromised by postpartum depression. Specifically, the University of Massachusetts (UMass), through its Office of Grant & Contract Administration, will use intersectional viral...
- This federal Project Grant award of $709,872 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop and pilot test a couple-based intervention to address perinatal depression and improve adherence to prevention of mother-to-child transmission (PMTCT) of HIV in Malawi. The key objectives are to: 1) develop a couple-based intervention using problem-solving therapy and content on couple...
- This Project Grant award of $157,000.00, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a longitudinal, prospective study investigating the relationship between pregnancy stress, maternal mental health symptoms, sex steroid hormones, and postpartum maternal sensitivity. The study aims to determine the individual and coordinated trajectories...
- This Project Grant award, funded by the Agency for Healthcare Research and Quality (AHRQ) under the Research on Healthcare Costs, Quality and Outcomes (CFDA 93.226) program, supports a comprehensive $398,972 study on improving healthcare quality and equity for newborns with prenatal substance exposure. The study, conducted by the University of California, Davis in collaboration with the Better Outcomes through Research for Newborns (BORN) network and the EMPOWER stakeholder group, aims to:...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $175,647 to the University of Pittsburgh to study biobehavioral markers of prenatal resilience and their association with positive postpartum maternal mental health and well-being. The study aims to examine how positive childhood experiences and prenatal biobehavioral resilience (e.g., higher heart rate variability, self-reported...
- This federal Project Grant award of $182,249, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the implementation and evaluation of a digitally enhanced intervention called EMPWR (Empowering Pregnant Women Receiving Medications for Opioid Use Disorder). The primary objectives of this grant are to: (1) Evaluate the feasibility of implementing the EMPWR intervention, which is designed to improve retention of pregnant...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $313,554 to Oregon Research Behavioral Intervention Strategies, Inc. (doing business as Influents Innovations) to develop and initially evaluate a prototype digital cognitive-behavioral therapy (CBT) intervention called "Parenting-Net." Parenting-Net is an unguided depression intervention designed to address moderate to mild depressive...
- The National Institute on Drug Abuse (NIDA) awarded a $193,752 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Boston Medical Center Corporation (BMC) to implement a video-coaching intervention entitled "THRIVE" to promote positive parenting behaviors for mothers with opioid use disorder (OUD). The project aims to integrate this evidence-based parenting intervention into pediatric primary care settings as a scalable model for engaging mothers...
- The U.S. Agency for Healthcare Research and Quality (AHRQ) awarded a $399,111 Project Grant under the Research on Healthcare Costs, Quality and Outcomes (CFDA 93.226) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant aims to increase postpartum primary care engagement, quality, and experience by strengthening coordination between obstetric and primary care providers. The intervention includes default primary care visit scheduling,...
EXAMINING THE ROLE OF IMPLEMENTATION STRATEGIES IN SUSTAINING EVIDENCE-BASED INTERVENTIONS IN HOME VISITING - PROJECT SUMMARY SUSTAINMENT OF EVIDENCE-BASED INTERVENTIONS (EBIS) IS A PRIORITY AREA FOR THE FIELD OF IMPLEMENTATION SCIENCE. HOWEVER, THERE ARE NOTABLE GAPS IN THE FIELD'S UNDERSTANDING OF HOW IMPLEMENTATION STRATEGIES PREPARE PRACTITIONERS TO SUSTAIN EBIS. MOTHERS AND BABIES (MB) IS AN EBI FOCUSED ON PREVENTION OF PERINATAL DEPRESSION THAT IS WIDELY IMPLEMENTED ACROSS HOME VISITING (HV) PROGRAMS THAT SERVE PREGNANT AND PARENTING INDIVIDUALS. SPECIFIC IMPLEMENTATION STRATEGIES HAVE BEEN DEVELOPED AND ARE BEING USED TO SUPPORT MB SUSTAINMENT IN HV PROGRAMS, WITH STATE HV NETWORKS IN NEW MEXICO AND RHODE ISLAND TRANSITIONING FROM AN INITIAL IMPLEMENTATION (0-24 MONTHS) TO SUSTAINMENT (24-36 MONTHS) PHASE DURING THE PROJECT PERIOD. THE PROPOSED R21 PROJECT WILL LEVERAGE THE RESEARCH TEAM'S PARTNERSHIP WITH THESE NETWORKS AND HAS TWO SPECIFIC AIMS. FIRST, WE WILL DETERMINE HOW EXISTING IMPLEMENTATION STRATEGIES PREPARE HV PROGRAMS TO SUSTAIN MB. WE WILL COLLECT ADMINISTRATIVE DATA TO ASSESS THE EXTENT TO WHICH MB IS SUSTAINED AT 24 MONTHS, INCLUSIVE OF PROVIDER- AND CLIENT-LEVEL SUSTAINMENT OUTCOMES. WE WILL ALSO ELICIT PERSPECTIVES FROM NEW MEXICO AND RHODE ISLAND HV MANGERS, STAFF, AND CLIENTS ON THE EXTENT TO WHICH SUSTAINMENT PREDICTORS ARE ASSOCIATED WITH FIDELITY OF IMPLEMENTATION STRATEGIES AND THE PERCEIVE USEFULNESS OF IMPLEMENTATION STRATEGIES IN PROMOTING MB SUSTAINMENT. ANALYSES WILL ALSO BE CONDUCTED EXAMINING THE RELATIONSHIP BETWEEN SUSTAINMENT PREDICTORS AND SUSTAINMENT OUTCOMES. QUALITATIVE DATA WILL ALSO BE COLLECTED TO ASSESS HOW IMPLEMENTATION STRATEGIES INFLUENCE SUSTAINMENT PREDICTORS AND SUSTAINMENT OUTCOMES, AS WELL AS MULTI-LEVEL CONTEXTUAL FACTORS THAT AFFECT HOW IMPLEMENTATION STRATEGIES ENHANCE SUSTAINMENT PREDICTORS AND SUSTAINMENT OUTCOMES. SECOND, WE WILL DEVELOP AND PILOT TEST AN IMPLEMENTATION STRATEGY "BUNDLE" TO SUPPORT MB SUSTAINMENT IN HV. WE WILL USE A HUMAN-CENTERED DESIGN APPROACH AND WORK WITH HV MANAGERS AND STAFF TO FINALIZE AN IMPLEMENTATION STRATEGY BUNDLE THAT SUPPORTS MB SUSTAINMENT IN HV, AND PILOT TEST THE NEW IMPLEMENTATION STRATEGY BUNDLE WITH TWO NEW STATE HV NETWORKS TO EXAMINE THE FEASIBILITY, ACCEPTABILITY, AND APPROPRIATENESS OF EACH STRATEGY. THESE ACTIVITIES WILL PREPARE US TO CONDUCT A R01 HYBRID-EFFECTIVENESS TYPE 2 TRIAL TESTING THE NEW IMPLEMENTATION STRATEGY BUNDLE AS WELL AS SUSTAINED MB IMPLEMENTATION AND EFFECTIVENESS AMONG HV PROGRAMS RECEIVING THE STRATEGY BUNDLE. PUBLIC HEALTH SIGNIFICANCE AND INNOVATION OF THIS PROJECT IS SUBSTANTIAL. PERINATAL DEPRESSION IS THE MOST COMMON HEALTH COMPLICATION ASSOCIATED WITH PREGNANCY, AFFECTING ONE IN FIVE WOMEN. HV PROGRAMS PROVIDE SERVICES TO PREGNANT AND PARENTING INDIVIDUALS ACROSS ALL 50 STATES. BY DEVELOPING A SUSTAINMENT MODEL FOR INTEGRATING MB INTO HV, THIS R21 WILL FACILITATE THE SUSTAINED DELIVERY OF MB, WHICH IS CONSISTENT WITH NIMH'S STRATEGIC OBJECTIVE TO SCALE-UP EVIDENCE-BASED PRACTICES AND GOAL OF PAR-22-109 TO IDENTIFY, DEVELOP, AND/OR TEST STRATEGIES FOR OVERCOMING BARRIERS TO THE SUSTAINABILITY OF EBIS. OUR SUSTAINMENT MODEL WILL ALSO SERVE AS A GUIDE FOR OTHER RESEARCH TEAMS SEEKING TO INTEGRATE AND SUSTAIN EBIS INTO HV.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.0k | 8/18/25 | ||
| Not listed | $240.0k | 6/27/24 |