Project Grant R21HL181478
- This federal Project Grant award of $551,863 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on how prostaglandin E2 (PGE2) regulates airway epithelial cells to balance liquid absorption and secretion. The research aims to establish new regulatory mechanisms controlling airway surface liquid volume, with the goal of identifying novel therapeutic targets for pulmonary diseases. The project is conducted by researchers at the...
- This federal Project Grant award of $248,999 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on mesenchymal cell plasticity and signaling in lung regeneration. The award aims to examine how specific mesenchymal cell lineages establish and maintain maladaptive epithelial regeneration after severe lung injury, such as from influenza or COVID-19. Key objectives include investigating the proliferation, plasticity, and Notch...
- This Project Grant award, valued at $498,991.40, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arkansas, Fayetteville. The goal is to engineer microphysiological systems with tight oxygen control to investigate the molecular pathways activated in oxygen gradients and the resulting effects on cardiomyocyte function, in order to obtain a comprehensive understanding of the cardiac response to hypoxic...
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This Project Grant award of $807,067.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to pioneer the quantitative documentation of human respiratory kinematic profiles. The study aims to address a critical gap in contemporary physiological monitoring - the inability to quantify labored breathing, which contains vital prognostic information not captured by conventional monitoring. Building on a recent innovation called ARK...
- This federal Project Grant award, funded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), aims to engineer a biomaterial platform to investigate how the extracellular matrix (ECM) influences airway basal stem cell (BC) self-renewal and differentiation. The $350,000 award, with a period of performance from Nov 1, 2024 to Oct 31, 2027, will be executed by the University of Iowa. The research seeks to create a new material that simulates the composition and stiffness of...
- The federal Project Grant award of $507,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop an automated system that integrates micro-electromechanical sensors, automation, and machine vision to simultaneously measure electrophysiological properties and contractile forces in single human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). This innovative system is expected to significantly reduce measurement time...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the mechanosensitive mechanisms underlying angiogenesis and lung regeneration. The $618,838 award to the Medical College of Wisconsin aims to investigate how mechanical stretching forces control angiogenesis during compensatory lung growth after pneumonectomy. The research will focus on the role of the focal adhesion protein paxillin in regulating...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,182,618 to Iowa State University of Science and Technology to develop an advanced "digital twin" technology for personalized cardiovascular care. The goal is to create a rapid, predictive modeling platform that can simulate heart valve disease progression and optimize long-term treatment interventions. The research aims to integrate scientific machine...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $422,075 to The University of Iowa to develop an electromagnetic-actuated, dynamic cell culture method for airway epithelial cells. The project aims to prototype a novel "Magniwell-12" system that integrates a porous PDMS membrane, membrane holder, magnetic actuator, and peripheral heat dissipation/control circuits. This will enable dynamic stretch-relax culturing of airway epithelial cells to better model the physiological motions of the airway and lung, with potential applications for studying pulmonary diseases and improving respiratory treatments. The award has an ultimate completion date of July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.1k | 8/11/25 |