Project Grant R21EB038487
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded $429,000 to the University of Colorado-Denver on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for a two-year project concluding March 31, 2028. The grant funds research focused on developing PLGA (poly(lactic-co-glycolic acid))-encapsulated phosphatase and tensin homolog (PTEN) nanoparticles as a...
- Federal Grant Award Summary The University of Colorado received a $594,533 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, effective May 1, 2026, through April 30, 2029, supports the development of novel magnetic nanotransducers designed to enable non-invasive neural stimulation for treating neurological conditions...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded University of Colorado-Denver a $429,000 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) for a two-year research initiative commencing September 1, 2025 and concluding August 31, 2027. The project investigates the impact of selective vagal neuromodulation on heart failure indices through optical neuromodulation techniques. The research will employ micro-resolution, three-dimensional...
- Federal Project Grant Summary: More Heart Transplants Through Informed Donor Selection New York University School of Medicine received a $165,672 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2030. This research initiative addresses the significant gap between heart transplant (HT) demand and supply in the United States by...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $468,000 to the University of Colorado-Denver under the Cardiovascular Diseases Research program (CFDA 93.837) for a two-year project period beginning August 1, 2025, and concluding July 31, 2027. This Project Grant supports secondary analysis research focused on identifying noninvasive imaging biomarkers for early prediction of single ventricle failure, a potentially lethal congenital heart defect...
- Federal Grant Award Summary The University of Colorado-Denver received a $776,754 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 15, 2025, with an ultimate completion date of April 30, 2030. This ancillary prospective longitudinal neurodevelopmental study, designated CAN-DO (COMPASS Ancillary Neurodevelopmental Outcomes), will evaluate long-term neurodevelopmental outcomes in neonates...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Colorado-Denver a Project Grant of $2,089,301 under the Cardiovascular Diseases Research program (CFDA 93.837) on May 1, 2025, with an ultimate completion date of February 28, 2029. This research grant supports an investigation into targeting the interleukin-17 (IL-17) inflammatory axis as a novel therapeutic approach for chronic thromboembolic pulmonary hypertension (CTEPH), a...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $553,217 to the University of Colorado-Denver on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Hat-Dependent Control of Cardiac Fibrosis," will extend through May 31, 2029, and focuses on understanding and developing targeted therapeutic interventions to prevent pathological fibrotic remodeling in the heart. The...
- Federal Project Grant Award Summary The University of Colorado received a $400,000 Project Grant award dated May 1, 2025, under the National Science Foundation (NSF) Engineering program (CFDA 47.041), administered by the Division of Chemical, Bioengineering, Environmental, and Transport Systems. The grant funds collaborative research to develop a high-speed 3D Dynamic Contrast Microscopic Optical Coherence Tomography (3D DYC-OCT) system—a label-free optical imaging technology designed to...
- This $349,999 federal Project Grant award was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award aims to develop a new biomaterial platform to investigate how the extracellular matrix influences airway basal stem cell self-renewal and differentiation. This research seeks to create a material that simulates the composition and stiffness of lung tissue,...
The University of Colorado-Denver received a $624,000 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective April 1, 2026 through March 31, 2028. This award supports the development and validation of a novel ex vivo delivery technology designed to improve heart transplant outcomes and expand the usable donor organ pool. The project involves engineering a polymeric sheet containing nanoparticles (NPs) with macrophage-specific targeting peptides, fluorescent markers for tracking, and macrophage activation inhibitors to reduce pro-inflammatory signaling and mitigate recipient neutrophil and monocyte recruitment following transplantation. The deliverable under this award is a bioengineering innovation that addresses critical limitations in heart transplantation, including waitlist mortality due to organ shortage and the burden of lifelong immunosuppression on recipients. By targeting the donor heart prior to transplant when directly accessible, the proposed technology aims to reduce acute rejection risk within the first year and chronic rejection over a five-year period. Although the initial application focuses on heart transplantation, the technology platform is designed to be applicable to other organs, potentially enabling broader utilization of previously discarded organs and improved post-transplant clinical outcomes across multiple transplant categories.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.0k | 3/30/26 |