The National Cancer Institute (NCI) has awarded a $434,542 Project Grant (CFDA 93.395 - Cancer Treatment Research) to the Icahn School of Medicine at Mount Sinai to develop a Drosophila (fruit fly) model to study the genetic susceptibility to adverse side effects, such as musculoskeletal pain, caused by aromatase inhibitor (AI) cancer drugs like letrozole, anastrozole, and exemestane. This 2-year project aims to use unbiased genetic screens and compound screens in the fly model to identify candidate therapeutics and genetic variants that contribute to AI toxicity. The goal is to match breast cancer patients with the specific AI they are most likely to tolerate from the outset, eliminating the need for a painful trial-and-error process of switching between AIs. The project leverages the rich set of Drosophila assays and tools to dissect the genetic basis of AI-induced side effects, with plans to validate the findings in mammalian models and patient datasets in the future.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $434.5k | 6/11/25 |