Project Grant R21CA302986
- The National Cancer Institute awarded a $176,040 Project Grant to The General Hospital Corporation (Massachusetts General Hospital) from July 1, 2025 to June 30, 2027 under the Cancer Research Manpower (CFDA 93.398) federal grant program. The goal of this project is to develop new strategies to engineer CAR-T cells that can overcome the cancer cell glycocalyx barrier in solid tumors. This will involve: (1) engineering CAR-T cells to strengthen the immune synapse by enhancing binding to the...
- This $195,766 federal Project Grant, awarded on December 19, 2024 by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research at Yale University to develop a mechano-transduction platform for enhancing chimeric antigen receptor (CAR) T-cell therapies for cancer immunotherapy. The key goals are to: 1) measure forces along immune receptors like the T-cell receptor and CAR using force sensors, and 2) engineer force transduction modules that can induce expression of...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $249,645 to Boston Children's Hospital to develop advanced genetic engineering techniques to study the role of tumor-specific B cells in cancer progression. The researchers aim to genetically modify B cells to target the HER2 tumor antigen, with the goal of using these engineered B cells as an adoptive immunotherapy to trigger both humoral and cellular anti-tumor immune responses. The...
- This $858,166 Project Grant awarded by the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) is for a randomized trial of a targeted palliative care intervention for patients with metastatic breast cancer. The grant supports a 5-year study to be conducted by The General Hospital Corporation (Massachusetts General Hospital) to improve documentation of end-of-life care preferences, delivery of end-of-life care, and patient-reported outcomes for this patient population....
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $2,054,733 in funding to The General Hospital Corporation (doing business as Massachusetts General Hospital) for a project titled "CAR T Cells Targeting Mesothelin and Secreting Bispecific Antibodies Targeting Fibroblasts in Pancreatic Cancer." The project aims to address key limitations of CAR T cell therapy for solid tumors by developing a novel approach using...
- This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $1,181,683 to the Dana-Farber Cancer Institute in Boston, MA to conduct research aimed at enhancing immune checkpoint blockade responsiveness and tertiary lymphoid structure formation through CD4+TFHx13 CAR-T cells to achieve cures for clear cell renal cell carcinoma (CCRCC). The research will involve experimental design and computational analysis of...
- The Defense Health Agency awarded a $732,825 Project Grant to The General Hospital Corporation (Massachusetts General Hospital) under the Military Medical Research and Development program (CFDA 12.420) for an extension of an artificial chromosome-based system as a novel delivery strategy for CAR-T cell therapy of ovarian cancer to human lymphocytes. This 3-year project, running from September 1, 2023 to August 31, 2026, aims to develop and validate new treatment approaches for ovarian cancer. As...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $604,627 to the Trustees of Dartmouth College to conduct research aimed at deconvoluting the heterogeneity of chimeric antigen receptor (CAR) T cells in order to engineer durable antitumor immunity. The research project, which runs from January 1, 2025 to December 31, 2029, will use dynamic lineage recording to understand how individual CAR T cell subsets behave in vivo and...
- The National Cancer Institute (NCI), under the federal Cancer Biology Research grant program (CFDA 93.396), awarded a $218,089 Project Grant to the University of California, Santa Barbara (UCSB) to develop and evaluate a novel chimeric antigen receptor macrophage (CAR-M) immunotherapy for the treatment of triple-negative breast cancer (TNBC). The project, titled "RAC-Enhanced Chimeric Antigen Receptor-Macrophage (RACE-CAR-M) Immunotherapy for Triple Negative Breast Cancer," aims to...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $176,040.00 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the effects of aging on CDC1 function and CD8 T cell immunity in tumors. The research aims to gain a better understanding of how age-related declines in immune function can impact the effectiveness of CD8+ T cell immunity and immunotherapy response in older cancer...
This Project Grant, awarded by the National Cancer Institute (CFDA 93.395 Cancer Treatment Research), provides $416,818 to The General Hospital Corporation, doing business as Massachusetts General Hospital, to conduct research aimed at improving the efficacy of chimeric antigen receptor (CAR) T-cell therapy for metastatic breast cancer. The key objectives of this research project are to evaluate whether physical activity can enhance the delivery and function of CAR-T cells in metastatic breast cancer by normalizing the tumor vasculature, alleviating hypoxia and immunosuppression in the tumor microenvironment. The project will use preclinical animal models to assess the impact of moderate-intensity exercise on tumor vasculature, immune cell profiles, and progression of metastatic breast cancers. Researchers will also analyze the effects of exercise on CAR-T cell infiltration and function in metastatic tumors. This research aims to identify strategies to improve the efficacy of CAR-T cell therapy for solid tumors like metastatic breast cancer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.8k | 7/29/25 |