The National Cancer Institute awarded a $225,101 Project Grant (CFDA 93.396 - Cancer Biology Research) to Childrens Hospital Medical Center to create a comprehensive "Splicing Neoantigen Atlas" of 30 adult and pediatric malignancies. The goal is to identify and experimentally validate diverse forms of splicing neoantigens - an untapped reservoir of common immunogenic targets for new cancer therapies. The researchers will employ innovative artificial intelligence approaches to accurately predict shared splicing neoantigens that could serve as the basis for broadly applicable immunotherapies. This work is expected to reveal thousands of highly shared splicing neoantigens derived from distinct regulatory mechanisms, which will be made accessible through an interactive web portal called "NEOxplorer" for further exploration and interrogation by the cancer research community.
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