Project Grant R21CA284221
Award Date
9/5/23
Completion Date
8/31/25
Dollars Obligated
$423K
Federal Agency
National Cancer Institute
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
Pasadena, CA 91125, USA
Similar Awards
This $417,586 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) will enable the Broad Institute of MIT and Harvard to develop a robust, multi-modal spatial genomics platform for profiling human tumors. The key products and services to be delivered under this 3-year project include: Extending the Institute's proprietary "Slide-Tags" technology to measure not only gene expression, but also epigenetic states and genomic variations...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research program) provides $424,734 to the University of Illinois to develop a novel spatial proteomics approach integrating 3D microscopy and bottom-up proteomic analysis. The goal is to offer deep proteome profiles of specific immune cells within different subregions of a tumor, in order to understand the spatially associated functions of immune cells in the tumor microenvironment. The project...
This Cooperative Agreement award from the National Cancer Institute (NCI) under the 21st Century Cures Act - Beau Biden Cancer Moonshot program (CFDA 93.353) provides $1,069,188 in funding to the California Institute of Technology (Caltech) for a project titled "Understanding the Role of Tumor Microenvironment in Low Grade Glioma Progression to Malignancy". The project aims to construct a comparative spatial atlas of low-grade gliomas to better understand the molecular and cellular...
The National Cancer Institute (NCI) awarded a $222,027 Project Grant (CFDA 93.396 - Cancer Biology Research) to the University of Pittsburgh to develop a novel computational imaging algorithm that can characterize the mechanobiological properties of the tumor microenvironment. The key objectives are to: Develop a computational imaging algorithm that can quantitatively capture the intrinsic mechanobiological properties of the cellular and acellular components within 3D tumor microenvironments,...
The National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), awarded a 2-year, $457,683 Project Grant to the Beckman Research Institute of the City of Hope to develop and evaluate novel "bio-beacon" therapies. The bio-beacons are engineered bacteria that secrete chemokines and cytokines to recruit and activate immune cells within solid tumors. The goal is to enhance the efficacy of immune checkpoint blockade therapies by increasing the density of...
The National Cancer Institute awarded a $483,041 Project Grant (CFDA 93.396 Cancer Biology Research) to Baylor College of Medicine to conduct research aimed at improving the efficacy of cancer immunotherapy using engineered T cells. The key objectives are to: 1) understand the molecular mechanisms regulating T-cell dysfunction in the tumor microenvironment, 2) enhance T-cell resistance to dysfunction through systematic engineering of transcription factors, and 3) determine the most effective...
The National Cancer Institute awarded a $240,092 Project Grant under the Cancer Biology Research (CFDA 93.396) program to the Scripps Research Institute in La Jolla, California. The purpose of this grant is to implement a new mass spectrometry-based protein footprinting technique called Covalent Protein Painting (CPP) to measure protein conformations in single cancer cells. The researchers aim to quantify lysine site accessibility in single cells using CPP-SCP (CPP for single cell proteomes) and...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $1,190,933 to SRI International for a project titled "Pilot In Vivo Trial with T-Cell-Based Delivery of Immunostimulatory Proteins". The goal is to develop a cell-based delivery system to localize high doses of immunostimulatory proteins within the tumor microenvironment to treat advanced solid tumors, such as high-grade serous ovarian cancer, without systemic...
The National Cancer Institute (NCI) awarded a $734,980 Project Grant under the Cancer Biology Research (CFDA 93.396) federal grant program to Aperture Bio, Inc., a woman-owned small business located in Boston, MA. The goal of this 1-year project is to commercialize a platform for rapid, single-cell proteomic profiling to enable improved diagnostic and treatment outcomes for cancer patients. The funded work aims to develop a validated panel for profiling immune cells, which can be used on...
This $435,827 Project Grant from the National Cancer Institute (NCI) under the CFDA 93.394 Cancer Detection and Diagnosis Research program supports research conducted by New York University (NYU) School of Medicine to develop deep learning methods for analyzing mass spectrometry imaging (MSI) data. The goal is to make MSI data more accessible to existing machine learning workflows by expanding the dimensionality of the data structure to treat each metabolite or lipid as an individual "color...