Project Grant R21CA282568

This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), provides $433,256 to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The funding supports research to identify novel targets and develop lead compounds to overcome resistance to KRAS inhibitors for lung, colon, and other cancers. The project leverages fragment-based chemoproteomics approaches to probe biological target space and discover targets associated with non-genomic resistance mechanisms. The goal is to identify unique targets and chemical leads that can be advanced for future drug discovery efforts targeting KRAS inhibitor resistant cancers.