Project Grant R21CA277663
- The University of Notre Dame Du Lac was awarded a $551,601 Project Grant by the National Cancer Institute under the Cancer Treatment Research federal grant program (CFDA 93.395) to develop isoform-selective inhibitors targeting the 90 kDa heat shock protein (Hsp90β) for the treatment of lethal prostate cancer. The project aims to create and optimize these Hsp90β-selective inhibitors that can effectively reduce cancer cell proliferation and enhance the efficacy of immune checkpoint blockade...
- This $622,340 Project Grant awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research conducted by the University of Notre Dame to develop multispecific bridge nanoparticles. The goal is to engage T cells and off-the-shelf CAR-T cells against antigen-positive endothelial cell (EC) tumors, with the aim of enhancing antitumor immune activity. The award period runs from June 1, 2025 to May 31, 2027. This grant demonstrates the...
- The University of Notre Dame was awarded a $430,375 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286) to develop innovative, long-lasting depots for delivering glucagon-like peptide 1 receptor agonists (GLP1-RAs) to treat diabetes and obesity. The project aims to engineer GLP1-RA therapies that can provide multi-month duration of therapeutic function through the use of self-assembling nanofibrillar systems. This research seeks to create GLP1-RA...
- The National Science Foundation awarded a $726,224 project grant to the University of Notre Dame du Lac through the Engineering program (CFDA 47.041) to support research on plasmonic bubble-enabled nanoparticle deposition under microgravity conditions from September 1, 2022 to August 31, 2025. The University will leverage the fluid flow dynamics around thermal bubbles on surfaces in microgravity to concentrate and deposit target molecules, with the aim of enhancing detectability for applications...
- The University of Notre Dame received a $250,000 project grant award from the National Science Foundation Division of Industrial Innovation. The award is part of the NSF Engineering program (CFDA 47.041) to support the development of 5-minute protein analyses from September 1, 2021 through February 28, 2023. The grant funding will allow the University to develop new techniques for rapidly analyzing protein compositions, with the goal of improving industrial biomanufacturing processes. The...
- The University of Notre Dame DU Lac's Notre Dame Research Division, doing business as the Office of Research, received a $471,006.00 Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The 3-year grant, awarded on September 15, 2023, supports a bench-bedside-bidirectional investigation of a new combinatorial immunotherapy strategy to treat platinum-resistant penile cancer. As a leading research university, the University...
- The University of Notre Dame received a two-year, $120,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program to develop next-generation, self-evolving implantable medical devices. Through the award ending April 2025, the university will research cross-layer co-design approaches allowing dynamic adjustment of detection algorithms and hardware configurations in implantable devices based on individual patient data and circumstances. The goal is to...
- The University of Notre Dame received a $491,300 Project Grant award from the National Science Foundation Division of Chemistry on September 1, 2021 to support research titled "SELF-IMMOLATIVE BOLAAMPHIPHILES FOR SIGNAL TRANSDUCTION ACROSS BILAYER MEMBRANES." The award will fund research through August 31, 2024 under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national scientific...
- This $625,756 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports the development of a high-throughput microfluidic platform called "Agarose Bead-based Digital Single Molecule-Single EV Sorting (BDEVS)" for ultra-sensitive profiling of individual extracellular vesicles (EVs) in plasma. The platform utilizes rolling circle amplification and flow cytometry-based readout/sorting to enable multiplexed, single-molecule...
- This Project Grant award of $939,000.00 was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) federal grant program. The funding supports research conducted by the University of Notre Dame's Notre Dame Research Division, known as the Office of Research, focused on analyzing the relationship between host obesity and therapeutic response in ovarian cancer. The project aims to advance understanding and treatment of this disease, with an...
The University of Notre Dame DU Lac received a $402,404 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to develop a scalable, continuous production platform for manufacturing therapeutic exosomes. The project aims to address key challenges in exosome-based drug delivery by: By integrating these innovative technologies, the project seeks to enhance the production rate, purity, and scalability of therapeutic exosome manufacturing for drug delivery applications. The award period runs from September 7, 2023 to August 31, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $402.4k | 9/7/23 |