Project Grant R21AR086411
- This $216,460 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research into the dysregulation of gamma secretase in common acquired hidradenitis suppurativa (HS). The research aims to define the enzymatic activity of gamma secretase and regulation of the nicastrin subunit in HS patient fibroblasts, as well as explore the impact of plastic-associated endocrine disruptors on...
- This Cooperative Agreement award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund a clinical trial to evaluate the efficacy and safety of anti-CD38 immunotherapy (isatuximab) for treating patients with severe hidradenitis suppurativa (HS). The $333,625 award will support a randomized, double-blinded, placebo-controlled, seamless Phase 2A/2B trial in HS...
- This federal Project Grant award, valued at $1,901,310.00 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project aims to investigate how skin inflammation drives the development of psoriatic arthritis, a condition that affects up to one-third of individuals with psoriasis. The project will use a novel mouse model to study the...
- This federal Project Grant award of $390,913 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support a mechanistic investigation into the role of the protein SERPINB3 in the pathogenesis of psoriasis. The research project, being conducted by Arizona State University, will explore the hypothesis that the misprocessing of SERPINB3 is the initiating factor in the...
- This Project Grant award, totaling $176,148.00 and effective from April 1, 2025 to March 31, 2030, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The funding supports a research project led by Dr. Maxime Kinet at the University of California, San Francisco (UCSF) that aims to elucidate the mechanisms by which PI16-expressing fibroblasts, a...
- The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
- The Hospital For Special Surgery Fund, Inc., doing business as HSS Foundation, received a $175,373 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Federal Grant Program (CFDA 93.846). The award, effective July 1, 2025 through June 30, 2030, will support the development and validation of novel methods to identify antiphospholipid syndrome (APS) in large patient cohorts and...
- This $250,396 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify differences in DNA regulatory elements that control gene expression in skin cells from individuals of different ancestral backgrounds. The research team at the Icahn School of Medicine at Mount Sinai will utilize advanced genomic techniques, including...
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- This federal Project Grant award of $102,341 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research at Stanford University to characterize the role of RNA-binding protein assemblies in epidermal homeostasis. The research aims to better understand how these protein complexes regulate keratinocyte proliferation and differentiation, which is critical for...
This federal Project Grant award of $366,053, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify the mechanisms of action of a novel, non-classical type I interferon (IFN) in the pathophysiology of hidradenitis suppurativa (HS). HS is a debilitating inflammatory skin disease that often leads to permanent scarring. The research aims to investigate the unique induction, signaling, and functional effects of this specific IFN subtype in HS, which could inform the development of new therapeutics that better target the disease pathophysiology while reducing adverse events. The award was granted to Pennsylvania State University's Milton S. Hershey Medical Center, which has demonstrated extensive capabilities in biomedical research, medical device development, and advanced scientific investigations across multiple disciplines.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $366.1k | 7/28/25 |