Project Grant R21AI195412
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $524,626 to the University of Wisconsin-Madison on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research titled "A Chromatin Loop Controls the Expression of Anterograde Transport Genes During HSV-1 Latency." The project, which extends through January 31, 2031, investigates the mechanisms governing herpes...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $232,558 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 13, 2026, with completion targeted for March 31, 2028. The grant funds research and development of an innovative gene therapy approach utilizing adeno-associated virus (AAV)-delivered meganucleases to achieve durable control of genital...
- Federal Grant Award Summary Tufts University School of Medicine received a $7.04 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanisms of nuclear egress in herpesviruses. The award, effective August 1, 2025, through July 31, 2029, supports research that expands understanding of how herpesviruses manipulate host cell membranes to export viral capsids from...
- Federal Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. The award funds basic biomedical research investigating fundamental aspects of Treponema pallidum (TPA) pathogenesis, specifically examining nutrient acquisition mechanisms and cyclic nucleotide...
- Federal Grant Award Summary The University of Connecticut received a $427,604 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on August 19, 2025. The award funds basic biomedical research directed by investigators at UConn's Storrs campus to elucidate the molecular mechanisms underlying conoid extrusion in Toxoplasma gondii, a parasitic pathogen that chronically infects...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $243,600 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 23, 2026, with completion scheduled for January 31, 2028. The award supports investigator-initiated biomedical research focused on elucidating the mechanism by which the host factor CLCC1 (C1F5LNUF7W86) facilitates membrane fusion...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Princeton University $133,600 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 24, 2025, with a completion date of March 31, 2027. This project grant supports investigator-initiated biomedical research into Herpes Simplex Virus Type 1 (HSV-1) infection mechanisms, specifically examining virus-induced chaperone enriched (VICE) domains and their role in...
- Federal Grant Award Summary The University of Connecticut received a $447,604 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 24, 2026 through January 31, 2028. This research initiative investigates the role of BipA, a conserved bacterial GTPase protein, in pathogenic mechanisms and antibiotic resistance. The project employs site-directed mutagenesis,...
- Federal Grant Award Summary The University of Connecticut Health Center received a $647,533 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. The award funds development of a rapid, affordable, and sensitive HIV viral load testing platform utilizing CRISPR cascade signal amplification technology. The project will investigate the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Kansas Center for Research Inc. a Project Grant of $411,499 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with completion scheduled for July 31, 2027. This research project seeks to establish poly(ADP-ribose) polymerase 14 (PARP14) as a novel host restriction factor that limits Herpes Simplex Virus 1 (HSV-1)...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Connecticut Health Center a Project Grant totaling $263,375 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 20, 2026 through March 31, 2028. This award funds biomedical research investigating HSV (Herpes Simplex Virus) alkaline nuclease as a novel antiviral drug target. The research focuses on understanding the UL12 gene-encoded alkaline nuclease in HSV1 and HSV2 replication pathways to develop new therapeutic agents capable of treating resistant viruses and addressing limitations of existing nucleoside/nucleotide-based antivirals, which are frequently associated with drug resistance, narrow spectrum activity, and dose-limiting toxicities. The project addresses significant public health challenges posed by genital herpes, including the lack of protective vaccines, inability to cure existing infections, risk of transmission to newborns, and associations with increased HIV infection risk. By identifying and characterizing this alternative HSV target, the research aims to generate scientific knowledge and therapeutic candidates that could enable new combination therapy approaches and prophylactic treatments to prevent viral reactivation, reduce pathological complications, and limit viral transmission between hosts.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $263.4k | 4/21/26 |