The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $127,302 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Michigan. The grant, awarded on January 18, 2025, supports research to understand how the integrated stress response (ISR) in macrophages shapes the innate immune response and infection outcomes during Salmonella enterica serovar Typhi (STy) infection. The research aims to reveal the role of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $219,122 to the University of Illinois to conduct research on Salmonella Typhimurium infection. The goal is to understand the mechanisms of gene regulation that control the bacteria's ability to infect and colonize host cells. The research focuses on characterizing a novel small RNA-mediated regulatory system that...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to model the impact of water, sanitation, and hygiene (WASH) interventions on reducing transmission of typhoidal Salmonella in the Indo-Pacific region. The $169,035 award, with a start date of September 11, 2024 and an ultimate completion date of August 31, 2029, will utilize data from the Revitalizing...
The University of California, Davis received a $225,839 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, titled "Vaccine Induction of Salmonella-Specific Th1 Memory Cells," aims to investigate the role of tissue-resident memory CD4 T cells in providing protection against systemic Salmonella infections, and to evaluate the use of an mRNA nanoparticle vaccine...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $256,995.00 to Tufts University School of Medicine to develop a generalizable strategy for linking quantitative measures of pathogen traits, such as fitness and iron starvation, to host cell mutations using optical sequencing. The project aims to overcome limitations in current approaches for evaluating...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research, will support research to investigate the genetic mechanisms that determine host susceptibility to low virulence strains of the Toxoplasma gondii parasite in mice. The $269,054 award, effective November 8, 2024 through October 31, 2026, will enable researchers at the University of California, Merced to leverage the...
This $4,004,843 Cooperative Agreement award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to advance the understanding of systemic and mucosal immunity to enteric bacterial pathogens like Salmonella and Shigella in children and adults. The award supports research projects that will use human-based models and specimens from clinical studies to examine the immunological...
This Project Grant award of $282,000 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to investigate the non-canonical, pyroptosis-independent role of host caspase-1 in regulating bacterial antimicrobial resistance (AMR) in intracellular pathogens like Salmonella. The research aims to elucidate the mechanism by which caspase-1 inhibits the PhoPQ two-component signaling system in...
This Project Grant award for $862,440.00 was made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports the development and evaluation of a new humanized mouse model to study gene editing therapies targeting chronic hepatitis B virus (HBV) infection. The key objectives are to: 1) Evaluate the anti-HBV efficacy of HBV gene therapy in liver-humanized NSG-PIZ mice, including assessing...