Project Grant R21AI190579
- This $162,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to investigate the mechanisms that maintain the longevity and functional diversity of memory CD8+ T cells in both circulating and tissue-resident populations. The research aims to elucidate how these memory T cell subsets are regulated by cytokines during homeostasis and in response to...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), CFDA 93.855 Allergy and Infectious Diseases Research program, supports research to investigate the role of Ly49 receptors on CD8 T cells. The $649,053 award to The Washington University in Missouri aims to better understand the functional contribution of Ly49 receptors and the transcription factor Helios to the development and function of CD8 regulatory T cells (Tregs). This research seeks to...
- This federal Project Grant award, valued at $735,078 and awarded on May 1, 2025, is provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant aims to unravel the molecular mechanisms of innate immune memory in humans, examining the epigenetic determinants that induce long-lasting "trained immunity" in human myeloid and lymphoid progenitor cells. Using single-cell gene expression...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $639,084 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to elucidate the functional heterogeneity of naive CD8 T cells, the precursors of effector and memory T cells that are critical for immune responses against pathogens and cancer. The 5-year project aims to provide a deeper understanding of...
- The Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $152,324 to The Leland Stanford Junior University to define the role of CXCL13 as an aging-associated defect in memory T cell homeostasis. The project, led by Dr. Casey Beppler, will leverage human immune organoid technology to reveal the mechanism of CXCL13-mediated maintenance of memory T cells (Aim 1) and determine the specific T cell...
- This federal Project Grant award of $3,147,392.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how dendritic cells initiate specific T helper (Th) cell responses to pathogens. The research aims to elucidate the innate sensing mechanisms by which dendritic cells drive the differentiation of Th1 versus Th17 lineage cells in response to distinct microbial...
- This $534,000 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of antigen location, peptide:MHCII complex density, and complex half-life as drivers of CD4+ T cell differentiation. The research, conducted by the Children's Hospital of Philadelphia, aims to provide clarity on how the strength of "Signal 1" (antigen...
- This Project Grant award, valued at $264,750, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports research on the regulation of dendritic cell positioning and function in lymph nodes, with a focus on understanding how integrin-mediated mechanisms optimize antigen presentation and the generation of anti-tumor immune responses. The project explores the role...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- The University of Maryland, Baltimore received a $427,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study CD27-mediated immune suppression by hematopoietic stem and progenitor cells (HSPCs), innate immune cells, or non-hematopoietic cells. The research aims to understand how the CD27-CD70 pathway regulates HSPC differentiation and function, and its potential role in modulating allogeneic T cell...
This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to support research on the cell-specific roles of CD153 and CD30 in regulating immune responses, particularly in the context of aging and immune function. The $441,375 award covers the period from Aug 1, 2025 to Jul 31, 2027 and was granted to the Children's Hospital Medical Center in Cincinnati, Ohio. The research aims to understand the mechanisms by which CD153 and CD30 signaling regulate immune responses in aging, with the goal of developing approaches to reinvigorate immune responses in the elderly. The award will fund experiments in aged mice to determine the impact of blocking CD153/CD30 signaling on antibody responses and germinal center B cell formation following immunization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.4k | 7/29/25 |