Project Grant R21AI189586
- Federal Project Grant Award Summary The University of Utah's Office of Sponsored Projects received a $423,500 Project Grant awarded on July 17, 2025, by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports investigator-initiated biomedical research examining the role of invariant natural killer T (iNKT) cells in Plasmodium infection pathogenesis, with completion targeted for June 30,...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Utah $423,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period extending from July 1, 2025 through June 30, 2027. This R21 Project Grant supports the development and evaluation of a novel chimeric antigen receptor T regulatory cell (CAR TREG) therapeutic design that targets programmed death-1 (PD-1) to enhance...
- Federal Grant Award Summary The University of Utah received a $743,752 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. This research project will investigate the epigenetic programming of CD4+ T cell dysfunction during chronic viral infections, with the goal of understanding how persistent antigen stimulation and inflammatory...
- Federal Grant Award Summary The University of Utah received a $3.08 million Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2029. This four-year research award funds investigative work on T cell receptor (TCR)-dependent and epigenetic mechanisms that guide influenza-specific CD4+ T cell responses in the lung. The research examines how primary...
- Federal Grant Award Summary The University of Utah's Office of Sponsored Projects received a $423,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 1, 2026 through January 31, 2028. The award funds investigator-initiated biomedical research examining the role of cholesterol metabolism in regulatory T cell (Treg) function and autoimmune disease. The research...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Utah $756,078 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 19, 2026, for a project grant extending through January 31, 2031. This research initiative investigates the mechanisms by which depleting anti-programmed death-1 (PD-1) antibodies interact with autoimmune environments in Type 1 Diabetes (T1D). The primary deliverable is scientific...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Utah a $153,799 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 12, 2025, with a completion date of July 31, 2027. This research project delivers molecular characterization services focused on understanding eosinophilic esophagitis (EOE), a chronic inflammatory disease of the esophagus. The grant funds RNA sequencing...
- Federal Project Grant Award Summary The University of Utah received a $423,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of July 22, 2025 and completion date of June 30, 2027. The grant funds research development of bispecific killer cell engagers (BiKEs)—a novel class of antibodies designed to selectively deplete programmed death-1 (PD-1) positive...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Utah a Project Grant of $625,348 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 3, 2025, for a five-year project period extending through June 30, 2030. This award funds basic immunological research investigating the gene regulatory network controlling memory B cell and long-lived plasma cell differentiation in response to vaccination...
- Federal Grant Award Summary The University of Utah, through its Office of Sponsored Projects Division, received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded November 23, 2025, with a completion date of June 30, 2028. This research project, titled "Innate Cells with Adaptive Specificity: Bond Kinetics of NK Cell Inhibitory Receptor Ly49C," supports...
The University of Utah received a $423,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with completion targeted for January 31, 2028. The award supports development and validation of a high-throughput screening (HTS) system and orthogonal assays designed to enable discovery of small molecule inhibitors targeting the Interleukin-25 (IL-25) signaling pathway. The project addresses a significant clinical need, as no existing drugs targeting IL-25 or its signaling pathway are currently available for treating IL-25-mediated inflammatory diseases, including allergic asthma. The research focuses on overcoming key barriers to small molecule drug development by establishing HTS-based hit identification and advancement strategies that target IL-25-specific signaling events upstream of the ACT1 adaptor protein, representing a defined "drug target window" for selective pathway inhibition. Successful completion of this exploratory R21 effort will generate validated screening systems and assay methodologies that support subsequent small molecule drug discovery efforts, providing tools to probe and therapeutically address IL-25-driven immune and inflammatory pathology.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 2/6/26 |