Project Grant R21AI188400
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $452,475 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Colorado State University (CSU) to study adaptive immune responses in bats. The project aims to determine the effector functions of helper and cytotoxic T cells in response to bat influenza A and coronavirus infections, and evaluate the impacts of vaccination and T cell depletion on infection control. CSU will use a captive...
- This $451,836 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), to The Washington University in Missouri. The purpose of the grant is to conduct a structural and mechanistic study of the bat NLRP6 inflammasome and its role in detecting RNA viruses, such as Ebola, Nipah, Hendra, and SARS-CoV, which bats can host without developing significant disease symptoms. The research...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $146,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Ghana to assess mechanisms for the persistence of RNA viruses in bat populations. The 5-year project, running from September 2025 to August 2030, aims to study virus prevalence, shedding, and spillover risk in captive and wild colonies of the straw-colored fruit bat (Eidolon helvum) in Ghana. The...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, awarded a $805,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai. The grant, awarded on November 20, 2024, supports a 5-year research project to elucidate the cellular tropism, receptor usage, and pathogenesis mechanisms of emerging bat-derived pararubulaviruses, which pose a potential global health...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $150,452 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Oklahoma. The grant will support a project titled "Molecular Testing of Predicted Bat Hosts for Zoonotic Hemoplasmas" from September 2025 to August 2027. The project aims to use machine learning models to prioritize bat species for molecular testing to identify potential zoonotic reservoirs of...
- This federal Project Grant award of $464,296 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the impact of bat hibernation on metabolism and immunity to infection. The award recipient, the University of Wisconsin System, will conduct studies to understand how temperature changes during hibernation affect the metabolic functions and immune responses of bat keratinocytes and...
- This Project Grant award of $376,932 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support research on the relationship between stress, migration, and viral shedding in Mexican free-tailed bats (Tadarida brasiliensis). The key objectives are to characterize coronavirus (CoV) diversity and infection status in bat populations, quantify stress physiology, and develop new cell lines...
- The University of Texas Southwestern Medical Center (UT Southwestern) received a $454,726 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this 5-year award, with a start date of July 9, 2025 and a completion date of June 30, 2030, is to investigate cell-intrinsic antiviral mechanisms in bats, focusing on interferon-stimulated genes (ISGs) and their evolutionary...
- This $814,512 National Science Foundation award under the Biological Sciences (47.074) program will fund collaborative research on integrated mechanisms of environment-host-virome interactions in Egyptian fruit bats. The University of California, Davis will lead the project to study how factors like food access, animal health, and immune responses influence viral infection levels in bat populations experiencing variable human exposure. Researchers will use integrative approaches to illuminate...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $134,577 project grant to the University of California, Los Angeles (UCLA) on January 26, 2025. The grant supports research to elucidate the molecular mechanisms by which encephalitic alphaviruses, such as Sindbis and Chikungunya viruses, can cross the blood-brain barrier and invade the central nervous system. Utilizing a stem...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $455,692 Project Grant to the University of California, Berkeley to conduct research on the mechanisms that underpin bat virus virulence. The goal is to experimentally test predictions from the research team's theoretical model by carrying out experimental evolution of Vesicular Stomatitis Virus (VSV) in bat cell cultures that exhibit varying levels of antiviral immunity and inflammation tolerance. The research will examine how these unique features of bat immunology and physiology impact the evolution of virus growth rates, which could lead to insights on why certain bat-borne viruses cause limited disease in bats but severe pathology in human hosts. The grant period runs from August 4, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $455.7k | 8/1/25 |