This Project Grant award of $647,187 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of heme synthesis in regulating regulatory T (Treg) cell fitness and function. The research aims to determine how the enzyme CPOX, critical for heme biosynthesis, promotes the proliferation, survival, and suppressive capacity of engineered Tregs. It also seeks to map the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) totaling $223,994 will support research to characterize the impact of transposable elements on cis-regulatory variation in human and mouse CD8+ T cell activation. The principal investigator will utilize single-cell sequencing, long-read sequencing, and in vitro phenotypic assays to validate the regulatory contribution of transposable elements to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $785,511 to the University of Chicago to conduct research on the genetic and epigenetic basis of inter-individual variation in immune responses to two deadly infectious agents, Mycobacterium tuberculosis and influenza virus. The key objectives are to: (1) characterize variability in immune responses to these...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $657,673 to the Regents of the University of Minnesota to conduct research on non-deletional CD8+ T cell tolerance. The research aims to define the gene regulation that inhibits self-reactive CD8+ T cells and classify different types of self-reactive CD8+ T cell clones, in order to understand which tolerance...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $195,819 to Duke University to conduct research on inducing xenotolerance via a chimeric thymus. The research aims to determine the ability of cultured postnatal pig thymus slices to attract human thymocyte precursors and antigen presenting cells, and support positive and negative selection in vivo in humanized...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $221,888 to the University of New Mexico Health Sciences Center to study the control of survival pathways in Th17 cells. The research aims to explore mechanisms for inducing Th17 cell apoptosis and evaluate potential applications of this approach using preclinical animal models. The award period runs from January 22,...
This Project Grant award of $226,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the mechanisms underlying robust innate immunity against Pneumocystis pneumonia (PCP) in the absence of CD4+ T cell function. The primary goals are to: 1) Define the early transcriptional profiles of lung epithelial cells from resistant and susceptible mouse strains upon interaction with...
This Project Grant award, totaling $744,977.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at Emory University to explore the role of T cells in providing protection against respiratory virus transmission. Key objectives include defining the cellular interactions and molecular mechanisms of tissue-resident memory T cells (TRM) that can limit the spread of...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine how germinal center (GC) responses are controlled in health and how governance loss promotes immune deficiencies and autoimmune diseases. The key objectives are to establish the lineage and functional differences between induced T follicular regulatory (iTFR) and natural TFR (nTFR) cells, and assess...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $534,000 to The Children's Hospital of Philadelphia (CHOP) over a period of approximately 2 years starting November 2024. The goal of the project is to study how the location of antigens and the density and half-life of peptide:MHC class II complexes on antigen-presenting cells impact the differentiation and...