Project Grant R21AI186003

Award Date 7/15/24
Completion Date 5/31/26
Dollars Obligated $445K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Columbus, OH 43205, USA
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The Project Grant award R21AI186003, valued at $444,600.00, was granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports research to investigate immune responses in infants with congenital syphilis infection, with the goal of identifying biomarkers that can distinguish congenitally infected infants from those who are syphilis-exposed but uninfected.

The research, to be conducted by the Research Institute at Nationwide Children's Hospital, a prominent non-profit research organization, will leverage advanced immunophenotyping techniques and serum cytokine/chemokine profiling to characterize the innate and adaptive immune responses in both symptomatic and asymptomatic infants with congenital syphilis. These findings will then be applied to the asymptomatic, syphilis-exposed infant cohort to determine if unique immunologic signatures can reliably identify those with true congenital infection. Ultimately, this project aims to provide new insights into the immunopathogenesis of congenital syphilis and develop potential biomarkers to improve clinical management of syphilis-exposed infants.

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