Project Grant R21AG091223
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $356,174 to The Regents of the University of California, San Francisco (UCSF) to conduct in vivo testing of structure-based vaccine candidates targeting Alzheimer's disease. The goal is to determine the efficacy of an active immunization strategy in preserving cognitive and neural function by slowing the formation of amyloid-beta or tau protein aggregation in the brain. The research will use...
- This federal Project Grant award of $817,357 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to harness novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's disease. The key products and services to be delivered under this grant include: Further validation of the grantee's "Variational Animal Motion Embedding (VAME)" machine learning platform for comprehensive behavioral phenotyping of...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a pilot study to evaluate the feasibility of using non-invasive neuroimaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The $332,096 award, with a performance period from July 2024 to June 2026, will be made to The General Hospital Corporation (doing business as Massachusetts General Hospital). The research...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $6,742,946 Project Grant to the University of Michigan to evaluate the effects of personalized brain stimulation as a potential treatment for individuals with posterior cortical atrophy (PCA), which is often caused by Alzheimer's disease. The 4-year study will use functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans to identify and target the...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $994,436.00 to Transchromix LLC to develop novel brain-penetrant drugs for treating Alzheimer's disease (AD). The key products and services being delivered include: Discovering a noncanonical, translation regulatory function of the histone methyltransferase G9A in AD pathogenesis using a chromatin-activity-based chemoproteomic (ChAC) approach to dissect AD heterogeneity. Deducing the mechanism...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,400 to Nova Southeastern University to conduct research comparing the therapeutic potential of three compounds - tirzepatide, retatrutide, and crocetin - in mitigating Alzheimer's-like pathology in a mouse model of comorbid Alzheimer's disease and obesity/prediabetes. The 3-year study, running from December 2024 to November 2027, will assess the impact of these interventions on...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $499,441 to Acepre, LLC to develop a novel brain-targeted delivery system for the compound N-acetylcysteine (TN-NAC) as a potential treatment for Alzheimer's disease (AD). The key objectives of this Phase I STTR study are to: 1) evaluate the toxicity and pharmacokinetic properties of TN-NAC in mice, and 2) test the therapeutic efficacy of TN-NAC in a 3xTG-AD mouse model of...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This Project Grant award for $398,046 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to systematically test the combined effects of anti-amyloid treatment and brain stimulation in a mouse model of Alzheimer's disease. The primary objectives are to assess the biochemical response, as well as memory and electrocorticography (ECoG) improvements, by exposing the 3xTG-AD mouse model to an anti-amyloid antibody treatment and a repetitive transcranial magnetic stimulation (rTMS) protocol. The research will be conducted by the Palo Alto Veterans Institute for Research (Pavir), a non-profit research organization closely affiliated with the VA Palo Alto Health Care System and Stanford University. The award period runs from Sep 5, 2025 to Aug 31, 2027. The goal is to develop an effective treatment strategy that combines pharmacological intervention to reduce amyloid plaque accumulation with brain stimulation to restore cognitive function for individuals suffering from mild cognitive impairment and Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $398.0k | 9/4/25 |