Project Grant R21AA032167
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $550,417 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Texas at Austin. The grant, effective September 1, 2025 through May 31, 2030, supports research to investigate how heavy alcohol exposure in aging individuals leads to impaired microglia function, neurodegeneration, and cognitive deficits. The study aims to determine whether dysregulated neuroimmune and microglia responses are...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $601,129 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The project, titled "Alcohol and Gut-Brain Axis and the Role of Butyrate on Neuroinflammation and Pain Sensitivity", aims to investigate the relationship between alcohol use disorder, chronic pain, and the gut microbiome, with a focus on the role of...
- The Project Grant award of $657,156.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research to examine the role of BK channels in alcohol-induced dysmyelination. The project aims to investigate the structural and functional correlates of myelin protein changes in a mouse model of alcohol use disorder, focusing on the effects of alcohol on oligodendrogenesis and pre-existing myelin. Key objectives include using...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a Project Grant of $180,939 to Yale University on September 1, 2025. The grant funding will support a study examining neurobiological threat reactivity as a potential biomarker for the comorbidity of chronic pain and alcohol use disorder (AUD). The project aims to use functional neuroimaging to investigate how the anterior insular cortex circuit function correlates with...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This Project Grant award of $123,045.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research on the role of the TRAF3IP2 protein in the development of alcohol-related cardiomyopathy. The project will investigate whether alcohol-induced cardiac fibroblast activation, proinflammatory cytokine expression, and extracellular matrix changes are dependent on TRAF3IP2, and whether deleting the TRAF3IP2 gene prevents alcohol-induced...
- The federal Project Grant award titled "Role of Functional Iron Deficiency in Alcohol-Associated Liver Disease" is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The $390,480 award, effective from September 10, 2025 to August 31, 2027, will support research at Emory University to investigate the molecular mechanisms underlying alcohol-associated mitochondrial dysfunction and its role in the progression of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $404,250 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Tennessee Health Science Center. The grant, awarded on September 23, 2025 with an ultimate completion date of August 31, 2027, supports research to explore the role of margaric acid in alcohol-associated liver diseases (AALD). The project aims to determine if margaric acid supplementation can attenuate alcohol-induced gut and liver...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $105,132 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kentucky Research Foundation. The grant, titled "Uncovering the Functional and Mechanistic Dysregulation of Monocytes After Abstinence and Post-Abstinence Drinking," will leverage a rhesus macaque model to investigate the persistent functional, transcriptional, and epigenetic changes in peripheral monocytes induced by...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the Alcohol Research Programs (CFDA 93.273), provides $224,969 to Emory University to conduct research on the mechanisms and treatments for alcohol-induced intervertebral disc degeneration. The research aims to elucidate the link between chronic alcohol consumption and the progression of painful disc degeneration, as well as evaluate the therapeutic potential of the drug pioglitazone in halting this degenerative process. Key aspects of the proposed work include assessing the impact of chronic alcohol on disc morphology, molecular changes, and biomechanical properties in mice, along with in-vitro studies to explore the underlying pathways. The award has a project period from September 5, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $225.0k | 9/3/25 |