Project Grant R16GM159703
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research...
- This Project Grant award of $421,829 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to explore mechanisms of lean mass recovery and tissue regeneration in migratory birds. The goal is to leverage this natural model to discover new mechanisms associated with tissue anabolism that could inform the development of effective therapeutics for recovery from cachexia, a condition characterized by...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $170,900.00 to Rowan University to conduct research aimed at optimizing autophagy to counteract aging-induced muscle deterioration in mice. The central hypothesis is that combining the autophagy agonist TAT-Beclin1 with endurance exercise may enhance the benefits of exercise in halting the progression of sarcopenia, or...
- The National Institute of General Medical Sciences (NIGMS) awarded a $183,125 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to the San Jose State University Research Foundation to study the biophysical effects of the cellular environment on the stability and aggregation of the tumor suppressor proteins p53 and PTEN. The research aims to systematically investigate how endogenous metabolites and post-translational modifications impact the conformational stability of...
- This $162,874 Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of Princeton University. The goal of this research project is to quantify protein dynamics and post-transcriptional regulation within the ectoderm germ layer of Drosophila (fruit fly) embryos. The researchers will use genetically modified Drosophila embryos expressing uniform morphogens to analyze...
- The National Institute of General Medical Sciences (NIGMS) awarded a $144,500 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to Charles R. Drew University of Medicine and Science. The grant will support research to investigate the mechanisms by which exercise training modulates endothelial lipid metabolism and vascular function. The research aims to identify molecular targets and develop "exercise in a dish" approaches to mimic the...
- The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a $223,176 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to examine the conditionality and time dynamics of evolutionary constraint in yeast. The project aims to leverage high-throughput microbial experimental evolution lineage tracking methods to generate quantitative insights into the dynamics of evolutionary constraint. Specifically, the...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $352,777 to support research into the regulation of sarcomere growth in skeletal muscle. The research aims to: 1) Identify molecular targets that impact sarcomere addition during muscle growth, and 2) Use in vivo protein tagging methods to study the dynamics of newly synthesized sarcomere...
- This federal Project Grant award of $565,826.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research conducted by Duke University to investigate how animals, using the C. elegans model organism, maintain developmental homeostasis and respond to fluctuations in nutrient availability. The research focuses on elucidating the role of key regulatory pathways, such as insulin/IGF signaling and...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $183,125 Project Grant to the San Jose State University Research Foundation. The grant, with a performance period from August 1, 2025 to July 31, 2029, will support a research project titled "Diet Promotes Muscle Stem Cell Activation and Proliferation in Drosophila." The project aims to decipher the mechanism by which diet and diet-responsive signaling pathways regulate the activation and proliferation of muscle stem cells. This research has the potential to provide new insights into how diet influences muscle growth, regeneration, and function during aging and muscle disease conditions, such as Duchenne muscular dystrophy. The project will be conducted by the San Jose State University Research Foundation, which has extensive experience in managing federal grants for advanced scientific research initiatives across various disciplines.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $183.1k | 8/1/25 |