Project Grant R15HL164682

This $888,000 project grant from the National Heart, Lung and Blood Institute will fund research into the role of oxidative signaling through Na/K-ATPase in chronic kidney disease-induced anemia. The awardee, Marshall University Research Corporation, will investigate how accelerated red blood cell eryptosis, or premature cell death, contributes to anemia development and progression in chronic kidney disease. Two specific aims will be pursued: 1) defining the role of adipocytes and global Na/K-ATPase-Src signaling in a mouse model of kidney failure-induced anemia, and 2) examining how Na/K-ATPase-Src signaling stimulates oxidative stress and red blood cell eryptosis using isolated red blood cells. Validation of the proposed signaling mechanisms could enhance understanding of anemia resulting from oxidative stress in conditions like hypertension, aging, obesity, and diabetes. This research is part of the Cardiovascular Diseases Research program (CFDA 93.837), which supports heart and vascular research through competitive grants.