Davidson College received a $761,042 Project Grant award from the National Institutes of Health's National Institute of General Medical Sciences to conduct genomic analysis of transcriptional regulation of cell identity from August 1, 2022 through July 31, 2025. The grant funds basic research to increase understanding of how transcription factors recognize specific DNA response elements and target genes to direct precise gene regulatory networks and establish distinct cell types. Researchers will use the model organism C. elegans and the nuclear hormone receptor NHR-25 to interrogate transcription factor binding and cell-type specific target gene regulation through genomic and genetic techniques including genome editing, chromatin binding assays, and analysis of C. elegans' compact genome structure. In addition to advancing knowledge of transcriptional regulation mechanisms, the project aims to train undergraduate scientists in cutting-edge genomic methods. The funding supports the Biomedical Research and Research Training program's goal of increasing understanding of biological processes foundational to disease advances.
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