Project Grant R15CA305552
Award Date 8/20/25
Completion Date 7/30/26
Dollars Obligated $576K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Michigan, USA
Similar Awards
- The federal Project Grant award of $186,250.00 was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Virginia to develop and characterize membrane-sensitive fluorescent probes for measuring local membrane environments of membrane proteins in living cells. The key objectives are to: 1) calibrate various fluorescent sensors to specific membrane structural parameters and determine their spatial sensing range, and 2) demonstrate proof-of-concept...
- The University of Michigan has been awarded a $568,151 Project Grant from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to develop a real-time functional imaging platform for accurate diagnosis and prognosis of prostate cancer. The project aims to leverage photoacoustic imaging and biocompatible hydrogel nanoparticle probes to quantitatively assess prostate gland microarchitecture and tumor microenvironment as imaging biomarkers for improved prostate...
- This $462,153 Project Grant was awarded on September 4, 2025 by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to Northern Michigan University (NMU). The grant will fund the development and utilization of a novel genetically encoded fluorescent biosensor, D2HGLO, to quantify intracellular concentrations of the oncometabolite d-2-hydroxyglutarate (d-2-HG) in cancer cells. This innovative tool will allow researchers to study the subcellular localization and...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $632,300 to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at subcellular resolution. The goal is to advance the application of spatial biology in cancer research by visualizing...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This Project Grant award of $573,470 from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) is supporting the development of a new Atomic Force Microscopy-Infrared Spectroscopic Imaging (AFM-IR) technology dubbed "Resonance Enhance Null-Deflection IR (RENDIR) Spectroscopic Imaging." The goal is to overcome limitations of existing AFM-IR systems to enable label-free, nanoscale chemical imaging of biological materials. The award will fund the...
- This Project Grant award of $1,249,099 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development of a new class of small, bright, tunable, and biocompatible near-infrared (NIR-II) fluorescent probes for deep tissue molecular imaging. The University of California, Irvine (UC Irvine) will create a palette of DNA-stabilized silver nanoclusters (AgN-DNA) that emit in the NIR-II tissue transparency window (1,000-1,700 nm). These new...
- This $671,072 federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) will fund the development of a novel microdevice to measure malignant lipid signaling in single cells from clinical samples. The University of Washington will lead a multidisciplinary collaboration to create a "picoliter thin-layer chromatography" (PTLC) chip and supporting hardware, integrating bioengineering, chemistry, and oncology expertise. This...
- This Project Grant award of $449,726.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Illinois aims to develop innovative tools for rapidly mapping dynamic changes in protein interactions within living cells. The goal is to enable the facile analysis of protein interaction changes occurring within one minute or less, which will significantly improve the sensitivity and temporal resolution of existing approaches. The project will explore three...
- This federal Project Grant award, valued at $375,337.00 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of photothermal mid-infrared single molecule super-localization microscopy to track the intracellular processes governing mRNA release from lipid nanoparticle (LNP) formulations. The goal is to provide...