This $133,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the Children's Hospital of Philadelphia (CHOP) to study sex differences in the impact of chronic social defeat stress on bladder voiding function and neurobiology in mice.
The research aims to: 1) Establish sex-specific effects of a novel chronic non-discriminatory social defeat stress paradigm on bladder voiding, histology, contractility, and neurohormone/receptor expression in the brainstem region controlling voiding; and 2) Determine the effects of gonadectomy in female and male mice on susceptibility to stress-induced bladder and brain changes. This work builds on the awardee's prior research and will provide preliminary data to support a future R01 application. The award period is from May 1, 2024 to April 30, 2026.
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