This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $621,073 to Vanderbilt University Medical Center (VUMC) to investigate cerebrospinal fluid dynamics in Huntington's disease.
The research aims to apply advanced neuroimaging techniques to comprehensively characterize aberrations in cerebrospinal fluid production, transport, and resorption across the progression of Huntington's disease. The project will differentiate choroid plexus pathology, analyze cerebrospinal fluid movement through the brain, and quantify anatomical changes in the parasagittal dural space. The data collected is intended to inform our understanding of Huntington's disease pathophysiology and identify potential biomarkers to guide future disease-modifying treatment trials. The award period runs from Jan 1, 2025 through Dec 31, 2029.