The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $835,288 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Pennsylvania State University for a 5-year research study on the mechanisms of cognitive impairment caused by atherosclerosis and red blood cell-released ATP. The research aims to investigate how atherosclerotic blockages in carotid and intracranial arteries lead to brain hypoperfusion, cerebrovascular remodeling, and neuroinflammation, resulting in cognitive impairment. The study will also examine the role of red blood cell-released ATP in atherosclerosis progression and the onset/worsening of cognitive deficits. Insights gained from in vivo, in vitro, and computational modeling experiments will advance understanding of the vascular contributions to cognitive impairment and dementia, informing potential prevention and treatment strategies.
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