This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, totaling $676,812.00, supports research to investigate the mechanisms of regulation of neuronal G protein-coupled receptors (GPCRs) by the potassium channel tetramerization domain (KCTD) family of proteins.
The research aims to: 1) Elucidate the molecular mechanisms of GABAB receptor/KCTD coupling using structural studies and biophysical analysis; 2) Probe the cellular mechanisms of KCTD regulation of GABAB receptor signaling through functional studies in cell lines and primary neurons; and 3) Characterize the novel signaling complex between the M5 muscarinic acetylcholine receptor and KCTDs using in vitro and live cell assays. The award also supports technology development efforts that may have broader utility in molecular neurobiology. Sub-awards are provided to researchers at MD Anderson Cancer Center and Harvard T.H. Chan School of Public Health to contribute mass spectrometry, biochemical, and structural expertise to the project.
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